T.-C. Wu, M.D., Ph.D.
| DEMOGRAPHIC INFORMATION Current Academic and Hospital Appointments: Professor of Pathology, The Johns Hopkins University School of Medicine Professor of Oncology, The Johns Hopkins University School of Medicine Professor of Obstetrics and Gynecology, The Johns Hopkins University School of Medicine Professor of Molecular Microbiology and Immunology, The Johns Hopkins University, Bloomberg School of Public Health Research Director of Gynecologic Pathology Pathologist, The Johns Hopkins Hospital Personal Data:
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RESEARCH ACTIVITIES Publications: Peer-Reviewed Scientific Articles: 1) J.M. McDonnell, P.J. McDonnell, P. Mounts, T.-C. Wu, and R. Green. (1985) Demonstration of papillomavirus capsid antigen in human conjunctival neoplasia. Archives of Ophthalmology Vol. 104, page 1801-1805. 2) H. Kashima, T.-C. Wu, P. Mounts, D. Heffner, A. Cachay, and V. Hyams.(1988) Carcinoma ex-papilloma: Histologic and virologic studies in whole-organ sections of the larynx. Laryngoscope Vol 98, No. 6, page 619-624. 3) T.-C. Wu, and P. Mounts (1988) Transcriptional regulatory elements in the noncoding region of human papillomavirus type 6. J. Virology Vol.62, No.12, pp 4722-4729. 4) T.-C. Wu, and P. Mounts.(1989) Sensitive detection of human papillomavirus nucleic acid and proteins in biopsy specimens of respiratory and genital tract papillomata. J.Virol. Meth. Vol. 26, pp 31-47. 5) T.-C. Wu, R.B. Mann, P. Charache, S.D. Hayward, S.Staal, B.C. Lambe and R.F. Ambinder. (1990) Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease. Int. J. Cancer Vol. 46, pp 801-804. 6) R.H. Hruban, T.-C. Wu, W.E. Beschorner, D.E. Cameron, R.F. Ambinder, W.A. Baumgartner, B.A. Reitz, G.M. Hutchins (1990) Cytomegalovirus nucleic acids in allografted hearts. Human Pathology Vol 21, pp 981-983. 7) J.S. Park, J.S. Rader, T.-C. Wu, L.A. Laimins, J.L. Currie, R.J. Kurman, and K.V. Shah. (1991) HPV-16 viral transcripts in vulvar neoplasia; preliminary studies. Gynecologic Oncology 42: 250-255. 8) T.-C. Wu, R.B. Mann, J. Epstein, E. MacMahon, W.A. Lee, P. Charache, S.D. Hayward, R.J. Kurman, G.S. Hayward, and R.F. Ambinder (1991). Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma: A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens: American Jour. Pathology 138:1461-1469. 9) T.-C. Wu, M.D. Kanayama, R.H. Hruban, W-C Au, F.B. Askin, and G.M. Hutchins (1991). Virus Associated RNAs (VA-I and VA-II): An efficient target for the detection of adenovirus infections by in situ hybridization. American Jour. Pathology 140: 991-998. 10) T.-C. Wu, R.H. Hruban, R.F. Ambinder, M.Pizzorno, D.E. Cameron, W.A. Baumgartner, B.A. Reitz, G.S. Hayward, and G.M. Hutchins (1991). Demonstration of cytomegalovirus nucleic acids in the coronary arteries of transplanted hearts. American Jour. Pathology 140: 739-747. 11) R.B. Mann, T.-C. Wu, R.F. Ambinder (1992). In situ localization of EBV in thymic carcinoma. Modern Pathology 5: 363-366. 12) T.-C. Wu, W.A. Lee, M. Pizzorno, W-C Au, R.H. Hruban, R.F. Ambinder, S.D. Hayward, G.M. Hutchins, and G.S. Hayward. (1992) Localization of the human cytomegalovirus (HCMV) 2.7-kb major early (beta) gene transcripts by in situ hybridization in permissive and non-permissive infections. American Jour. Pathology 141: 1247-1254. 13) T.-C. Wu, M.C. Pizzorno, G.S. Hayward, S. Willoughby, D.A. Neumann, N.R. Rose, A.A. Ansari, K.L. Baughman, and A. Herskowitz. (1992). In situ detection of human cytomegalovirus immediate early gene (IE) transcripts within cardiac myocytes of patients with HIV-associated cardiomyopathy. A.I.D.S. 6: 777-785. 14) H.K. Kashima, T. Kessis, R.H. Hruban, T.-C. Wu, J. Zinreich, and K.V Shah. (1992) Human papillomavirus in sinonasal papillomas and squamous cell carcinoma. Laryngoscope 102(9): 973-976. 15) T.-C. Wu, and T.-T. Kuo. (1993). Detection of Epstein-Barr virus early RNA (EBER1) expression in thymic epithelial tumors by in situ hybridization. Human Pathology 24: 235-238. 16) T.-C. Wu, M.D. Kanayama, W. Whitehead, and M.B.K. Raj. (1993) Detection of neuron specific 9.0 kb transcript which share homology with antisense transcript of HIV gag genome from the brain of both normal and AIDS individuals. American Jour. Pathology 142: 25-31. 17) T.-C. Wu, J.Trujillo, H. Kashima and P. Mounts (1993) Association of human papillomavirus and nasal neoplasia. Lancet 341: 522-524. 18) A. Herskowitz, S. Willoughby, T.-C. Wu, W.E. Beschorner, D.A. Neumann, N.R. Rose, K.L. Baughman, and A.A. Ansari. (1993) Immunopathogenensis of HIV-1- Associated Cardiomyopathy. Clinical Immunology and Immunopathology, 68.2: 234-241. 19) M.M. Oliva, T.-C. Wu and V.W. Yang. (1993) Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. Arch. Biochem. and Biophy. 302: 183-192. 20) L.D. Loren, D.S. Coffey, T.-H. Chen, T.-C. Wu, and G.R. Pasternack. (1993) A novel 32 kDa nuclear phosphoprotein is selectively expressed in cells competent for self-renewal. Cancer Research 53, 4720-4726. 21) J.A. DiGiuseppe, T.-C. Wu, and R.L. Corio. (1994) Analysis of Epstein-Barr virus-encoded small RNA 1 expression in benign lymphoepithelial salivary gland lesions. Modern Pathology 7, 555-559. 22) S. Hall, T.-C. Wu, N. Soudi, M.E. Sherman. (1994) Low-grade squamous intraepithelial lesions: Cytologic predictors of biopsy confirmation. Diagnostic Cytopathology 10.1: 3-9. 23) L. Hedrick, K.R. Cho, E.R. Fearon, T.-C. Wu, K.W. Kinzler, and B. Vogelstein. (1994) The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes & Development 8: 1174-1183. 24) A. Herskowitz, T.-C. Wu, S.B. Willoughby, D.A. Vlahov, A. Ahmed-Ansari, W.E. Beschorner and K.L. Baughman. (1994) Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late stage infection with human immunodeficiency virus. J. Am Coll Cardiol 24: 1025-32. 25) E. M. Burke, D. L.Karp, T.-C. Wu, and R. L. Corio (1994) Atypical oral presentation of herpes simplex virus infection in a patient after orthotopic liver transplantation. Eur Arch Otorhinolaryngol 251(5): 301-303. 26) J.A. DiGiuseppe, T.-C. Wu, B.A. Zehnbauer, P.R. McDowell, J.M. Barletta, R.F. Ambinder, and R.B. Mann. (1995) Epstein-Barr virus and progression of Non-Hodgkin's lymphoma to KI-1-positive, anaplastic large cell phenotype. Modern Pathol.8: 553-559. 27) T.-C. Wu, Y. Ling, M.D. Kanayama, A.Y.C Huang and R.J. Kurman. (1995) Localization of Epstein-Barr Virus-Encoded small RNA-1 (EBER-1) by in situ reverse transcription: Demonstration of cDNA generation in tissue sections. J. Biomed. Sci.2: 249-255. 28) S.-T. Tsai, Y.-Tai Jin, and T.-C. Wu. (1995) Synthesis of PCR-Derived, Digoxigenin- Labeled DNA Probes for EBER In Situ Hybridization. J. Virol. Meth. 54: 67-74. 29) T.-C. Wu, A. Y.C. Huang, E. M. Jaffee, and D. M. Pardoll (1995) A reassessment of the role of B7-1 expression in tumor rejection. J. Exp. Med. 182: 1415-1421. 30) T.-C. Wu, F.G. Guarnieri, K.F. Staveley-O'Carroll, R.P. Viscidi, H.I. Levitsky, L. Hedrick, K.R. Cho, J.T. August, and D.M. Pardoll (1995) Engineering a novel pathway for MHC Class II Presentation of Antigens. Proc. Natl. Acad. Sci. 92: 11671-11675. 31) K.-L. Liaw, A.W. Huang, C.-J. Chen, M.H. Schiffman, T.Y. Zhang, C.-Y. Hsieh, C.E. Greer, S.-L. You, T.W. Huang, T.-C. Wu, T.J. O'Leary, J. Seidman, W.J. Blot, C.L. Meinert, M.M. Manos. (1995) Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan. Int. J. Cancer 62: 565-571. 32) K.-Y. Lin, F. G. Guarnieri, K. F. Staveley-O'Carroll, H. I. Levitsky, J. T. August, D. M. Pardoll and T.-C. Wu (1996) Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Research 56:21-26. 33) O.B. Inge, G.J.A. Offerhaus, W.S.El-Deiry, T.-C. Wu, G.M. Hutchins, E.K. Kasper, K.L. Baughman, W.A. Baumgartner, C.-J. Chiou, G.S. Hayward, and R.H. Hruban. (1996) The WAF1-mediated p53 growth suppressor pathway is distinct in the coronary arteries of heart transplant recipients. Human Pathology 27(4): 324-329. 34) J.Trujillo, T.-C. Wu, and P. Mounts (1996) Characterization of human papillomavirus type 57b: Transforming activity and comparative sequence analysis as probes for biological determinants associated with high-risk oncogenic viruses. Virus Genes 12 (2): 165-178. 35) A.W., Hsing, R.D. Burk; K.-L. Liaw, C.-J.Chen, M.H. Schiffman,T.Y. Zhang,C.E. Greer,S.-L. You, C.-Y. Hsing, T.W. Huang, T.-C. Wu, T.J. O'Leary, J. D. Seidman, and M. Manos.(1996) Inter-laboratory variation in PCR-based human papillomavirus DNA assay. Cancer Epidemiology, Biomarkers & Prevention. 5(6):483-484. 36) A.G. Ramos-Soriano, J.M. Saavedra, T.-C. Wu, R.A. Livinggston, R.A. Henderson, J.A. Perman, R.H. Yolken (1996) Enteric pathogens associated with gastrointestinal dysfunction in children with HIV infection. Molecular Cell Probes. 10: 67-73. 37) I.O. Baas, J.A. Offerhaus, W.S. El-Deiry, T.-C. Wu, G.M. Hutchins, E.K. Kasper, K.L. Baughman, W.A. Baumgartner, C.J. Chiou, G.S. Hayward, R.H. Hruban (1996) The WAF1-mediated p53 growth-suppressor pathway is intact in the coronary arteries of heart transplant recipients. Human Pathol. 27: 324-329. 38) T.-C. Wu, D.A. Fuentes-Bernardo, Y.-J. Chan, W.-C. Au, C.-J. Chiou, W.M. Fox III, R.H. Hruban, G.S. Hayward, and R.J. Kurman. (1997) Temporal distribution of the human cytomegalovirus (HCMV) 2.0 kb immediate early gene transcripts in permissive and non- permissive infections by RNA in situ hybridization. J. Biomed. Sci. 4: 19-27. 39) Y.T. Jin, S.T. Tsai, C.Li, K.C. Chang, J.J. Yan, W.Y. Chao, H.L. Eng, T.Y. Chou, T.-C. Wu, and I.J. Su (1997) Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media. American Jour. Pathology 150: 1327-1333. 40) D.E. Mold, T.-C. Wu, F. Askin, and R.C.C. Huang (1997) Four classes of HERV-K long terminal repeats and their relative promoter strengths for transcription. J Biomed Sci, 4: 78-82. 41) T.-C. Wu, S.-T. Hsieh, B. W. Purow, and R. J. Kurman (1997) Demonstration of human papillomavirus (HPV) genomic amplification and viral-like particles from CaSki cell line in SCID mice. J.Virol. Methods 65: 287-298. 42) K.-Y. Lin, W. H. Westra, H. K. Kashima, P. Mounts, and T.-C. Wu (1997) Coinfection of HPV-11 and HPV-16 in a case of squamous laryngeal papilloma with severe dysplasia. Laryngoscope 107: 942-947. 43) A. Lafond-Walker, C.-L. Chen, S. Augustine, T.-C. Wu, R.H. Hruban, and C.J. Lowenstein (1997) Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis. Am J Pathol. 151(4): 919-925. 44) K. Vu, D.L. Greenspan, T.-C. Wu, H.A. Zacur, R.J. Kurman (1997) Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist treated uterine leiomyomas. Human Pathology. 29:359-363. 45) I.-M. Shih, T.-L. Wang, T.-C. Wu, R.J. Kurman, and J. D. Gearhart (1998) Expression of Mel-CAM in implantation site intermediate trophoblastic cell line, ITS-1, limits its migration on uterine smooth muscle cells. J. Cell Sci. 111: 2655-2664. 46) H. Ji, E.Y. Chang, K.-Y. Lin, R.J. Kurman, D.M. Pardoll, and T.-C. Wu (1998) Antigen specific immunotherapy for murine lung metastatic tumors expressing HPV-16 E7 oncoprotein Int. J. Cancer 78:41-45. 47) C.-C. Huang, J.-T. Qiu, M.L. Kashima, R.J. Kurman, and T.-C. Wu (1998) Generation of type-specific probes for the detection of single copy human papillomavirus by in situ hybridization with catalyzed reporter deposition system. Modern Pathology 11:971-977. 48) K.D.Kenneth, S.Q. Yang, H.Z. Lin, J. Chatham, V.P. Chacko, J.B. Hoek, E. Walajtys-Rode, A. Rashid, C.-H. Chen, C.C. Huang, T.-C. Wu, M.D. Lane, A.M. Diehl (1999) Obesity induce expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem. 274: 5692-5700. 49) C.-C. Huang, M.L. Kashima, H. Chen, I.-M. Shih, R.J. Kurman, and T.-C. Wu (1999) Cerebellar metastasis of cervical carcinoma presenting discordant histologic patterns. Human Pathology, 30: 587-591. 50) A. Rashid, T.-C. Wu, C.C. Huang, C.-H. Chen, H.Z. Lin, S.Q. Yang, F.Y.J. Lee, A.M. Diehl (1999) Mitochondrial proteins that regulate apoptosis and necrosis are induced in rat liver. Hepatology, 29: 1131-8 51) H. Ji, T.-L.Wang, C.-H. Chen,S. I. Pai, C.-F. Hung, K.-Y. Lin, R. J. Kurman, D. M. Pardoll and T.-C. Wu (1999) Targeting HPV-16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine HPV-16 E7-expressing tumors. Human Gene Therapy, 10: 2727-2740. 52) C.-H. Chen, H. Ji, K. W. Suh, M. A. Choti, D. M. Pardoll and T.-C. Wu (1999) Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs. Gene Therapy, 6: 1972-1981. 53) C.-H. Chen, T.-L. Wang, C.-F. Hung, D. M. Pardoll and T.-C. Wu (2000) Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines. Vaccine, 18: 2015-2022. 54) C.-H. Chen, T.-L. Wang, C.-F. Hung, Y. Yang, H. Chen, R. A. Young, D. M. Pardoll and T.-C. Wu (2000) Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Research, 60:1035-1042. 55) T.-L. Wang, M. Ling, I.-M. Shih, T.Pham, S.I. Pai, Z. Lu, R.J. Kurman, D.M. Pardoll, and T.-C. Wu (2000) Intramuscular administration of E7-transduced dendritic cells generates the most potent E7-specific antitumor immunity . Gene Therapy, 7: 726-733. 56) E.Y. Chang, C.H. Chen, H. Ji, T.-L. Wang, K. Hung, B.L. Lee, A.Y.C. Huang, R.J. Kurman, D.M. Pardoll, T.-C. Wu (2000) Antigen-specific cancer immunotherapy using an GM-CSF secreting allogeneic tumor cell-based vaccine. Int. J. Cancer, 86: 725-730. 57) C.-H. Chen, K. W. Suh, H. Ji, M. A. Choti, D. M. Pardoll, and T.-C. Wu (2000) Antigen-specific immunotherapy for metastatic tumors in the liver. J. Hepatology 33: 91-98. 58) N.R. Chu, H.B. Wu, T.-C. Wu, L.J. Boux, M.I. Siegel and L.A. Mizzen (2000) Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumor by administration of a fusion protein comprising Mycobacterium bovis Bacille Calmette-Guerin (BCG) hsp65 and HPV-16 E7 Clin. Exp. Immunol. 121: 216-225. 59) E.L. Hinton, L.D. Bobo, T.-C. Wu, R.J. Kurman and R.P. Viscidi (2000) Detection of Chlamydia trachomatis deoxyribonucleic acid in archival paraffinized specimens from chronic salpingitis cases using the polymerase chain reaction. Fertility and Sterility. 74: 152-157. 60) S.A. Leachman, R.E. Tigelaar, M.Ahylankevich, M.D. Slade, M. Irwin, E. Chang, T.-C. Wu, W. Xiao, S. Pazhani, D. Zelterman and J. L. Brandsma (2000) GM-CSF priming plus papillomavirus E6 DNA vaccination: Effects on papilloma formation and regression in the CRPV-rabbit model. J. Virol. 74: 8700-8708. 61) C.-H. Chen, T.-L. Wang, H. Ji, C.-F. Hung, H. C. Jen, D. M. Pardoll and T-C. Wu (2000) Recombinant DNA vaccines protect against tumors that evade recombinant vaccinia vaccines containing the same gene. Gene Therapy 8: 128-138. 62) W-F. Cheng, C.-F. Hung, K.-F. Hsu C.-Y. Chai, L. He, M. Ling, L. A. Slater, R. B.S. Roden and T.-C. Wu (2001) Enhancement of sindbis virus self-replicating RNA vaccine potency by targeting antigen to endosomal/lysosomal compartments. Human Gene Therapy 12: 235-252. 63) W.-F. Cheng, C.-F. Hung, C.-Y. Chai, K.-F. Hsu, L. He, C. M. Rice, M. Ling, and T.-C. Wu (2001) Enhancement of sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium Tuberculosis heat shock protein 70 gene to an antigen gene. J. Immunol. 166: 6218-6226. 64) C.-F. Hung, K.-F. Hsu, W.-F. Cheng, C.-Y. Chai, L. He, M. Ling and T.-C. Wu (2001) Enhancement of DNA vaccine potency by linkage of antigen gene to a gene encoding the extracellular domain of Flt3-ligand. Cancer Research. 61: 1080-1088. 65) K.-F. Hsu, C.-F. Hung, W.-F. Cheng, L. He, M. Ling and T.-C. Wu (2001) Enhancement of suicidal DNA vaccine potency by linking Mycobacterium Tuberculosis heat shock protein 70 to an antigen. Gene Therapy 8: 376-383. 66) C.-F. Hung, W.-F. Cheng, K.-F. Hsu, C.-Y. Chai, L. He, M. Ling and T.-C. Wu (2001) Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen. Cancer Research. 61: 3698-3703. 67) C.-F. Hung, W.-F. Cheng, Chai, C.-Y., K.-F. Hsu, L.He, M. Ling and T.-C. Wu (2001) Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen. J. Immunol. 166: 5733-5740. 68) W.-F. Cheng, C.-F. Hung, C.-Y. Chai, K.-F. Hsu, L. He, M. Ling and T.-C. Wu (2001) Enhancing sindbis virus self-replicating RNA vaccine potency by linkage of herpes simplex virus type 1(HSV-1) VP22 protein to antigen. J Virology 75:2368-2376. 69) J. D. Heller, J. Kuo, W. M. Kast, T.-C. Wu and R.-C. C. Huang (2001) Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo. Cancer Research 61: 5499-5504. 70) C.-C. Huang, W.-H. Wu, C.-Y. Chai, T.-C. Wu and J. H. Chuang (2001) Congenital prepubic sinus: A variant of dorsal urethral duplication suggested by immunohistochemical analysis. J. Urology 166: 1876-1879. 71) W.-F. Cheng, C.-F. Hung, C.-Y. Chai, K.-F. Hsu, L. He, M. Ling and T.-C. Wu (2001) Cancer treatment through anti-tumor immunity and anti-angiogenesis induced by a chimeric DNA vaccine encoding calreticulin linked to a tumor antigen. J. Clin. Invest. 108: 669-78. 72) A. Lamikanra, Z.-K. Pan, S.N. Isaacs, T.-C. Wu and Y. Paterson (2001). Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8+ T cell responses that home to the tumor site. J. Virol. 75: 9654-9664. 73) G. R. Gunn, A. Zubair, C. Peters, Z.-K. Pan, T.-C. Wu and Y. Paterson (2001) Evaluation of listeria monocytogenes vaccines that express HPV E7 as immunotherapeutics against HPV immortalized tumors. J. Immunol. 167: 6471-6479. 74) W.-F. Cheng, C.-F. Hung, K.-F. Hsu, C.-Y. Chai, L. He, J. M. Polo, L. A. Slater, M. Ling, and T.-C. Wu (2002) Cancer immunotherapy using sindbis virus replicon particles encoding a VP22-antigen fusion. Human Gene Therapy 13: 553-568. 75) C.-F. Hung, L. He, J. Juang, T.-J. Lin, M. Ling, and T.-C. Wu (2002) Improving DNA vaccine potency by linking Marek’s disease virus type 1 VP22 to an antigen. J. Virol. 76: 2676-2682. 76) W.-F. Cheng,C.-F. Hung, S. I. Pai, K.-F. Hsu , L. He, M. Ling, and T.-C. Wu (2002) Repeated DNA Vaccinations Elicited Qualitatively Different Cytotoxic T Lymphocytes and Improved Protective Antitumor Effects. J Biomed Sci. 9: 675-687. 77) W.-F. Cheng,C.-F. Hung, K.-Y. Lin , M. Ling, J. Juang, L. He,C.-T. Lin and T.-C. Wu (2003) CD8+ T cells, NK cells and IFN-g are important for control of tumor with down-regulated MHC class I expression by DNA vaccination. Gene Therapy. 10:1311-1320. 78) C.-Fu Hung, W.-F. Cheng, L. He, M. Ling, J. Juang, and T.-C. Wu (2003) Enhancing MHC class I antigen presentation by targeting antigen to centrosomes. Cancer Research. 63: 2393-2398. 79) T. W. Kim, C.-F. Hung, M. Ling, J. Juang, L. He, J. M. Hardwick, S. Kumar, and T.-C. Wu (2003) Enhancing DNA vaccine potency by co-administration of DNA encoding anti-apoptotic proteins. J. Clin. Invest. 112: 109-117. 80) C. Trimble, C.-T. Lin , C.-F. Hung, S. Pi, J. Juang, L. He, M. Gillison, D. Pardoll, Lee Wu, and T. -C. Wu (2003) Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine 21: 4036-4042. 81) T.W. Kim,, C.-F. Hung, D. Boyd, J. Juang, L. He, J. W. Kim, J. M. Hardwick, and T.-C. Wu (2003) Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life with Intracellular Targeting Strategies. J. Immunol. 171: 2970-2976. 82) C.-T. Lin, C.-F. Hung, J. Juang, L. He, K.-Y. Lin, T. W. Kim, and T.-C. Wu (2003) Boosting with Recombinant Vaccinia Increases HPV-16 E7-Specific T cell Precursor Frequencies and Antitumor Effects of HPV-16 E7- Expressing Sindbis Virus Replicon Particles. Molecular Therapy 8: 559-566. 83) T. W. Kim, C.-F. Hung, D. Boyd, L. He, D. Kaiserman, P. I. Bird, and T.-C. Wu (2004) Enhancement of DNA Vaccine Potency by Co-administration of Tumor Antigen Gene and DNA Encoding Serine Protease Inhibitor-6 (Serpinb9). Cancer Research 64: 400-405. 84) T.W. Kim, C.-F. Hung, J. Juang, L. He, J. M. Hardwick and T.-C. Wu (2004) Enhancement of Suicidal DNA Vaccine Potency by Delaying Suicidal DNA-Induced Cell Death Gene Therapy (in press) 85) C.-J. Hsieh, T. W. Kim, C.-F. Hung, J. Juang, M. Moniz, D. Boyd, L. He, and T.-C. Wu (2004) Enhancement of Vaccinia Vaccine Potency by Linkage of Tumor Antigen Gene to Gene Encoding Calreticulin. Vaccine (revised) 86) T. W. Kim, C.-F. Hung, M. Zheng, D. Boyd, L. He, S. I. Pai, and T.-C. Wu (2004) A DNA vaccine co- expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T cell immune response . J. Biomed. Sci. (in press) 87) T. W. Kim, C.-F. Hung, J. W. Kim, J. Juang, L. He, and T.-C. Wu (2004) Vaccination with DNA Vaccine Encoding HSV-1 VP22 Linked to Antigen Generates Long-Term Antigen-Specific CD8+ Memory T Cells and Protective Immunity. Human Gene Therapy (in press) 88) J. W. Kim, C.-F. Hung, J. Juang, L. He, T. W. Kim, D. K. Armstrong, S. I. Pai, C.-T. Lin, and T. -C. Wu (2004) Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies. Gene Therapy (in press). 89) T. W. Kim, J. H. Lee, C.-F. Hung, S. Peng, R. Roden, M.-C. Wang, R. Viscidi, Y.-C. Tsai, L. He, P.-J. Chen, D. Boyd and T. -C. Wu (2004) Generation and characterization of DNA Vaccines Targeting the Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus. J. Virol. (in press) 90) T. W. Kim, C.-F. Hung, M. Zheng, D. Boyd, L. He, S.I. Pai and T. -C. Wu (2004) A DNA vaccine co- expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T cell immune response. J. Biomed. Sci. (in press) Editorials, Reviews and Book Chapters: 1) P. Mounts, T.-C. Wu, Brigid Leventhal, H. Kashima, H. Dedo, G. Singleton, S. Gall, P. Weck, and J. Whisnant . (1985) Analysis of human papillomavirus type 6 in the respiratory and genital tracts during interferon therapy. Papillomaviruses: molecular and clinical aspects, page 137-154, Alan R. Liss, Inc. 2) P. Ward, T.-C. Wu, and P. Mounts (1987) RNA probes to analyze human papillomavirus gene expression in squamous papilloma of the respiratory tract. Cancer cells 5: papillomaviruses. page 73-78. 3) T.-C. Wu, and P. Mounts (1990) Cell type specific enhancer element in the non-coding region of human papillomavirus type 6. Papillomaviruses, page 463-473, Wiley-Liss, Inc. 4) T.-C. Wu, E.M.E. MacMahon, J. Zhang, B. Lambe, P. Charache, R.B. Mann, J. Epstein, S.D. Hayward and R.F. Ambinder. (1991) EBER1 small nuclear RNA in malignancy: A morphologically distinctive target for detection of EBV in formalin-fixed paraffin-embedded specimens. Epstein-Barr virus and Human disease 1990. Editior D.V. Ablashi, The Human Press Inc., New Jersey, pp. 163-167. 5) R.F. Ambinder, T.-C. Wu, B. Lambe, J. Zhang, P. Charache, B.A. Zehnbauer, G.S. Hayward and R.B. Mann. (1991) Absence of EBV in Reed-Sternberg cells in many cases of Hodgkin's disease, Epstein-Barr virus and human disease 1990. Editor D.V. Ablashi, The Human Press Inc., New Jersey, pp. 277-281. 6) Shi, Y.F and Wu, T.-C. (1997) Commentary. Advances in Biomedical Sciences. The Fourth Joint Annual Symposium of NIH/FAD CAA and Washington DC Chapter of SCBA. J. of Biomedical Sciences. 4:192. 7) S.L. Stevenson and T.-C. Wu (1999) Experimental vaccine strategies for cancer immunotherapy: Potential application to the development of HPV vaccines. Editor R. Tindle, Landes Bioscience. Chapter 9: pp 149-172. 8) S. Kadkol, J. Juang, and T.-C. Wu (2003) In situ hybridization in cancer and normal tissue. Editor Wafik S. El-Deiry: Tumor suppressor genes: Methods and protocols; Methods in molecular medicine series. The Human Press Inc., New Jersey, Chapter 5: pp 51-72. 9) M. Ling and T.-C. Wu (2004) Therapeutic HPV Vaccines. Editor Tom Rohab and Keerti Shah: Cervical Cancer : From Etiology to Prevention. The Kluwer Academic Publishers. Dordccht (in press) Inventions and Patents: 1) Improved Heat Shock Protein (HSP) DNA Vaccines (DM-3570)-US-filed on October 20, 1999, USSN 09/421,608 2) Heat shock protein (HSP) DNA Vaccines (DM-3620-Novel Strategy to Enhance DNA Vaccine Potency)- CIP-filed on February 2, 2000, USSN 09/501,097 3) Chimeric Immunogenic Compositions and Nucleic Acids Encoding Them (DM-3570/DM3668)-US/PCT- filed on October 20, 2000 4) Fusion of Calreticulin (CRT) to Antigens Enhances the Potency of DNA Vaccines (DM-3661/DM 3693- Sindbis Virus)-US-filed on February 9, 2000, USSN 09/501,097 5) Compositions and Methods for Inducing and Enhancing Immune Responses Using Intercellular Transport Polypeptide Chimerics (DM-3719-VP-22)-US Provisional filed August 1, 2000, USSN 60/222,185 6) Enhancing Sindbis Virus Self-replicating RNA Vaccine Potency by Linkage of Herpes Simplex Virus Type1-(HSV-1) VP22 Protein to Antigen (DM-3758) 7) Cancer Vaccine Linking DNA Encoding the Translocation Domain of a Bacterial Toxin to a Tumor Antigen (DM-3794) 8) Superior Molecular Vaccines (DNA, Self-Replicating RNA or Suicidal DNA) Linking Nucleic Acid Encoding Heat Shock Protein or FLT3-Ligand to Nucleic Acid Encoding the Antigen (DM-3797) 9) Novel Strategy to Enhance Vaccine Potency by Targeting Antigen to Centrosome (Microtubule Organization Center) (DM-3814) 10) Enhancement of DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen (DM-3895) 11) Development of Mesothelin-Specific Cancer Immunotherapy Using an Ascitogenic Ovarian Tumor Model (DM-4083) 12) Boosting with Recombinant Vaccinia Increases HPV-16 E7-Specific T cell Precursor Frequencies and Antitumor Effects of HPV-16 E7-Expressing Sindbis Virus Replicon Particles (DM-4173) 13) Enhancement of Suicidal DNA Vaccine Potency by Delaying Suicidal DNA-Induced Apoptotic Cell Death (DM-4176) 14) Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies (DM-4178) 15) Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life with Intracellular Targeting Strategies (DM-4223). 16) Enhancement of DNA Vaccine Potency by Co-administration of Tumor Antigen Gene and DNA Encoding Serine Protease Inhibitor-6 (DM-4262) EDUCATIONAL ACTIVITIES Teaching: Classroom Instruction: 1) Unit Director (Gyn/Breast/Prostate) of Pathobiology and Disease Mechanisms Course, 2002, 2003 (JHU, School of Medicine) 2) Lecture in the Second Year Pathology Course for second year medical students on “Pathology of the cervix”. 2002 (JHU, School of Medicine). 3) Lecture in the Second Year Pathology Course for second year medical students on “Pathology of the vulva and vagina”. 2002 (JHU, School of Medicine). 4) Coordinate and teach the Gynecology Pathology section for medical students in the Second Year Pathology Laboratory. 1998-present (JHU, School of Medicine). 5) Teach virology and bacteriology for medical students in the Second Year Pathology Laboratory. 1999-2000 (JHU, School of Medicine). 6) Lecture in Pathobiology Course for graduate students on “Preclinical model for vaccine development”. 2001, 2002, 2003 (JHU, School of Medicine). 7) Lecture in the Immunology Graduate Program Journal Club Series for graduate students on “New strategies for vaccine development”. 2001, 2002 (JHU, School of Medicine). 8) Lecture in Graduate Immunology for graduate students on “Tumor immunology”. 2001 (JHU, School of Hygiene and Public Health). 9) Lecture in “Principle of Virology” for graduate students on “Carcinogenesis and human papillomavirus”. 2001 (JHU, School of Hygiene and Public Health). 10) Lecture in “ Advanced Virology” for graduate students on “Human papillomavirus and Oncogenesis” 2002, 2003 (JHU, School of Hygiene and Public Health). 11) Lecture in “Viral Oncology” for graduate students on “Human papillomavirus and Oncogenesis” 2003 (JHU, School of Medicine). 12) Lecture in “Biologic Basis of Vaccine Development” for graduate students on “Cancer Vaccines” 2003 (JHU, School of Hygiene and Public Health). Clinical Instruction: 1) Teaching Gynecology and Pathology residents at Gynecology teaching conferences. 2) Teaching Gynecology and Pathology residents to use the multiheaded microscope. 3) Teaching in the Emil Novak Memorial Course on “ HPV vaccine development”. 2000 (5th Richard W. TeLinde Lecture). Other Instruction: Lecture in A Woman’s Journey series on “Cancer Vaccines”, 2000 (a community education series sponsored by the Johns Hopkins Medical Institutions). Mentoring (pre and post-doctoral): Undergraduate Students: Edwin Y. Chang (1996-1998; currently, a third year medical student at the University of Michigan, School of Medicine) Stephen Brian Chiang (1996; currently, a fourth year medical student at the University of Illinois, School of Medicine) Sunny Young (1996; won the 1996 Provost's Undergraduate Research Award; currently, a second year dental student at UCLA) Howard Jen (1998, 1999 summer; currently, a second year medical student at University of Maryland School of Medicine) Morris Ling (1999-present; won the 2000 Provost's Undergraduate Research Award; currently, a Medical Student at the University of Maryland School of Medicine) Thu Pham (1999, 2000 summer; won the 2000 Howard Hughes Undergraduate Research Award; currently, a second year medical student at the University of Pennsylvania) Kaveh Nabavighadi (1999 summer; currently a senior undergraduate student at Johns Hopkins) Leigh Slater (1999-2001, currently, a second year medical student at Emory University) Amit N. Vora (2001 spring; recipient of the Woodrow Wilson Undergraduate Research Fellowship; currently, a sophomore undergraduate student at Johns Hopkins) Aimee Wu (2001 spring; currently, a junior undergraduate student at Johns Hopkins) Jeremy Juang (2001; recipient of the 2001 Provost’s Undergraduate Research Award; currently, a senior undergraduate student at Johns Hopkins) Stellios Karnezis (2001 spring; currently, a junior undergraduate student at Johns Hopkins) Michelle Moniz (2001-present; recipient of the Woodrow Wilson Undergraduate Research Fellowship; currently, a junior undergraduate student at Johns Hopkins) Manesh Dagli (2001 summer; currently, a senior undergraduate student at Johns Hopkins) Richard Dzeng (2001 and 2002 summers; currently, a freshman undergraduate student at Princeton University) Medical Students: Masahide Kanayama, M.D. (1992, Medical Student from University of Wisconsin, School of Medicine; currently, an Assistant Professor in the Department of Obstetrics and Gynecology at the Mount Sinai Hospital in New York) Anthony L. Lee, M.D. (1992; Medical Student at Hopkins; currently, a fifth year resident in the Department of Surgery at the University of Michigan Medical Center) Maciej Lesniak, M.D. (1995; Medical Student at Hopkins; currently, a fifth year resident in the Department of Neurosurgery at the Johns Hopkins Hospital) Stefanie L. Stevenson, M.D. (1997, Medical student at Hopkins; currently, a third year resident in the Department of Medicine at the University of Cincinnati Medical Center) Nazanin Hanjani (1999 summer; currently, a fourth year Medical student at Hopkins) Graduate Students: Ken-Yu Lin, (B.C.M.B. Graduate Program; recipient of the 2000 Howard Hughes Graduate Student Research Award; currently pursuing a thesis on the mechanisms of tumor evasion in Dr. Wu’s lab) Bruce Huang (Pathobiology Graduate Program, currently pursuing a thesis on the mechanisms of tumor metastasis in Dr. Wu’s lab) Jesse Rowley (Immunology Graduate Program, currently pursuing a thesis on the mechanisms of DNA vaccines in Dr. Wu’s lab) Jian-Tai Qiu (Molecular Microbiology and Immunology Graduate Program, rotating student) Cecily Alcock (Immunology Graduate Program, rotating student) Sasha Klevytska (Pathobiology Graduate Program, rotating student) Yan Zheng (Immunology Graduate Program, rotating student) Stina Fengmark (Pathobiology Graduate Program, rotating student) Yen-Chun Liu (Pathobiology Graduate Program, rotating student) Andrew (Hung-Chih )Yang (Immunology Graduate Program, rotating student) Chuan-Hsiang Huang (Immunology Graduate Program, rotating student) Residents: Matthew L. Kashima, M.D. (1998 January-1998 July; currently, an Assistant Professor in the Department of Otolaryngology Head and Neck Surgery of the Johns Hopkins Bayview Medical Center) Post-Doctoral Fellows: Teh-Ying Chou, M.D., Ph.D. (1995-1996; Post-doctoral Fellow; currently, an Associate professor in the Department of Pathology at the Veterans General Hospital in Taiwan) C.-C. Huang, M.D. (1997-1998; post-doctoral fellow; currently, an attending pathologist and Assistant Professor in Chang-Gung Memorial Hospital in Taiwan) Hongxiu Ji, M.D., Ph.D. (1996-1998; post-doctoral fellow; currently, an Instructor in the Department of Pathology at the Johns Hopkins Hospital) Chien-Hung Chen, M.D. (1998-1999; post-doctoral fellow; currently, an Assistant Professor in the Department of Medicine at National Taiwan University Hospital) Mingxin Che, M.D., Ph.D. (1998-1999; postdoctoral fellow; currently, an Assistant Professor at Wayne State Hospital, Detroit) Chien-Fu Hung, Ph.D. (1998-2000; postdoctoral fellow; currently, an Assistant Professor in the Division of Gynecologic Pathology of the Johns Hopkins Hospital) Wen-Fang Cheng, M.D. (1999-2001; postdoctoral fellow; currently, an Assistant Professor in the Department of Obstetrics and Gynecology at the National Taiwan University Hospital) Keng-Fu Hsu, M.D. (1999-2000; postdoctoral fellow; currently, an Assistant Professor in the Department of Obstetrics and Gynecology of the National Cheng Kung University Hospital) Chai Chee-Yin, M.D., Ph.D. (1999-2000; postdoctoral fellow; currently, Chairman of the Department of Pathology at the Kaohsiung Medical University, Taiwan) Chia-Ling Hsieh, M.D. (2000-2002, postdoctoral fellow; currently, an attending physician at the Chang-Gung Memorial Hospital in Taiwan) Jeong Won Kim, M.D., Ph.D. (2001-2002, postdoctoral fellow; currently, an Assistant Professor in the Department of Internal Medicine at the Dankook University Medical Center in South Korea) Cheng-Tao Lin, M.D. (2001-2003, postdoctoral fellow, currently, an Instructor in the Department of Obstetrics and Gynecology of the Chang-Gung Memorial Hospital in Taiwan) Tae Woo Kim, Ph.D. (2001-2003, postdoctoral fellow, Currently, an Research Associate in the Department of Pathology of the Johns Hopkins Hospital) Graduate Student Thesis Committees: Yue-Ming Huang (Molecular Microbiology and Immunology Graduate Program, M.S. Degree, 1999, Thesis Advisory Committee) Shiwen Peng (Immunology Program at the University of Queensland, Australia, Ph.D. Degree, 1999, outside reviewer) Jonathan Heller (Biochemistry Graduate Program, Ph.D. Degree, 2000, Thesis Advisory Committee) Jie Yang (Molecular Pharmacology Graduate Program, Ph.D. Degree, 2001, oral examiner) Haili Zhang (Immunology Graduate Program, Ph.D. Degree, 2001, oral examiner) Gladys Tan (Immunology Graduate Program, Ph.D. Degree, 2001, oral examiner) Rebecca Garten (Molecular Microbiology and Immunology Graduate Program, Ph.D. Degree, 2001, oral examiner) Jian-Tai Qiu (Molecular Microbiology and Immunology Graduate Program, Ph.D. Degree, 2001, Thesis Advisory Committee) Tian-Hong Wang (Immunology Graduate Program, Ph.D. Degree, 2001, Thesis Advisory Committee) Lan Lin (Pharmacology Graduate Program, Ph.D. Degree, 2001, Thesis Advisory Committee) George R. Gunn, III (Immunology Program at the University of Pennsylvania, Ph.D. Degree, 2001, outside reviewer) Kai Wei Lin (Immunology program, Ph.D. Degree, 2002, oral examiner) Loise Francisco (Immunology Program, Ph.D. Degree, 2002, oral examiner) Kalpana Devaraj (Molecular Microbiology and Immunology Program, M.H.S. Degree, 2002, Thesis Advisory Committee) Ruijiang Song (Biomedical Engineering Program, Ph.D. Degree, 2002, Chair of Thesis Advisory Committee) Patti Gravitt (Epidemiology Graduate Program, Ph.D. Degree, 2002, Thesis Advisory Committee) Phuong Thi Nguyen Sarkis (Molecular Microbiology and Immunology Graduate Program, Ph.D. Degree, 2003, oral examiner) Training grant participation: 1) Immunology Graduate Program Training Grant, 2001-present, trainer 2) Pathobiology Graduate Program Training Grant, 2000-present, trainer 3) NIH T32 STD Training Grant, 2001-present, member of the executive committee for laboratory research Editorial Activities: Editorial Board 2000-present Diagnostic Molecular Pathology Journal peer review activities: 1. Journal of Biomedical Science 2. The Laryngoscope Journal 3. International Journal of Gynecological Pathology 4. Journal of the society for Gynecologic Investigation 5. Cancer Research 6. Clinical Cancer Research 7. American Journal of Pathology 8. Expert Opinion on Investigational Drugs 9. Journal of Virology 10. Modern Pathology 11. The Lancet 12. Cancer Epidemiology, Biomarkers and Prevention 13. Human Pathology 14. Molecular Pathology 15. Journal of Immunology 16. Cancer Immunology and Immunotherapy 17. Virology 18. Human Gene Therapy 19. FASEB 20. Molecular Therapy 21. Gene Therapy 22. Blood 23. Journal of the National Cancer Institute 24. Nature Medicine CLINICAL ACTIVITIES Certification: 1992 - present State of Maryland License 1992 American Board of Pathology, Certification in Anatomic Pathology Service Responsibilities: a) Regularly sign out diagnostic GYN surgical pathology specimens. b) Participate in the development of new molecular diagnostic tests. c) Participate in the development of new molecular immunological assays. ORGANIZATION ACTIVITIES Institutional Administrative Appointments:
Professional Societies: American Society for Clinical Investigation American Association of Immunologists Sigma Xi Society of Chinese Bioscientists in America (SCBA) Binford-Dammin Society (devoted to the promotion of research in pathology emphasizing infectious diseases) American Association for Cancer Research International Society of Gynecological Pathologists American Society of Gene Therapy American Society for Microbiology International Papillomavirus Society Conference Organizer, Section Chair: 1) Organizer for the Fourth Annual Joint Scientific Symposium of NIH/FDA CAA and Washington DC Chapter of SCBA, August, 1997, Bethesda, Washington D.C. 2) Organizer for the Fifth Annual Joint Scientific Symposium of NIH/FDA CAA and Washington DC Chapter of SCBA, August, 1998, Bethesda, Washington D.C. 3) Moderator and member of the Program Committee for the Companion Meeting/Scientific Symposium of the Binford-Dammin Society of Infectious Disease Pathologists, International Academy of Pathology 2001, Atlanta, Georgia. 4) Chair for Immunology Section of the 19th International Papillomavirus Conference 2001, Florianopolis, Brazil. 5) Moderator and member of the Program Committee for the Companion Meeting/Scientific Symposium of the Binford-Dammin Society of Infectious Disease Pathologists, International Academy of Pathology 2002, Chicago, Illinois 6) Chair for AAI tumor immunology program "Anti-tumor Effector Cells and Regulation of Tumor Immunity" 2002, New Orleans, Louisiana 7) Chair and member of the Scientific Program Committee for Prophylactic Vaccines section of the 20th International Papillomavirus Conference 2002, Paris, France. 8) Chair and member of the Program Committee for the Companion Meeting/Scientific Symposium of the Binford-Dammin Society of Infectious Disease Pathologists, International Academy of Pathology 2003, Washington D.C. Advisory Committee, Review Group: 1. Ad hoc member of NIH Experimental Immunology (EI) Study Section, 2000, 2001 2. Grant review for National Institute of Health, Taiwan, R.O.C., 2000 3. Grant review for National Science Foundation, USA, 2000 4. Grant review for South Carolina Research Initiative Grants, 2000 5. Grant review for Department of Veterans Affairs, 2000 6. Grant review for California Breast Cancer Research Program, 2000 7. Grant review for Dutch Cancer Society, 2000, 2001 8. Grant review for Austrian Science Fund, 2001 9. Grant review for the Ireland Health Research Board, 2001 10. Grant review for National Science Council, Taiwan, R.O.C., 2000, 2002 11. Grant review for American Institute of Biological Sciences / Flight Attendant Medical Research Institute, 2001 12. Grant review for the Rapid Access to Preventive Investigational Development (RAPID) program, 2001, 2002 13. Grant review for the Research Grants Council of Hong Kong, 2002 14. Grant review for the Department of Defense, United States Government, 2002 15. Member of the site visit committee to the Paterson Institute at Manchester, England, Cancer Research Campaign, 2002 16. Member of the site visit committee to the National Health Research Institutes of Taiwan for Center Development Grant, 2002 17. Member of NIH Experimental Immunology (EI) Study Section, 2002 18. Member of the site visit committee to program project (2PO1 CA078673-05) at Duke University, Durham, 2002 19. Member of the site visit committee to Laboratory of Cellular Oncology (Drs. John Schiller and Douglas Lowy) at the National Cancer Institutes of the National Institutes of Health, Bethesda, Maryland, 2003 Consultantships: Genencor International, Inc., January 2002 through January 2004, consultant Cerus Corporation, January 2003 through January 2005, consultant RECOGNITION Awards, honors: National Taiwan University, College of Medicine 9/75-6/82 Book Award, 1975 through 1982 for being in top five percent of the class 1979 Dr. Shu Yeh Scholarship (best student in Pathology) Johns Hopkins University, School of Hygiene & Public Health 1986-1988 The Hampil Fellowship (tuition and stipend support) 1987 The Frederick B. Bang Award (for an outstanding research idea in the area of pathobiology) 1989 The Delta Omega Honorary Society Alpha Chapter (in recognition of excellence in student research) International Academy of Pathology 1994 Binford-Dammin Award (from Binford-Dammin society of International Academy of Pathology.) The Passano Foundation 1996 Passano Physician Scientist Award Society of Chinese Bioscientists in America 2000 Outstanding Service Award Invited Talks, Panels: 1994 "Transcriptional activation of HPV by human cytomegalovirus (HCMV) and detection of HCMV immediate early transcripts in a subset of HPV containing condylomata." Invited speaker, University of Chicago, Pritzker Medical School, Illinois. 1994 "Development of vaccine and immunotherapeutic strategies for HPV related cervical carcinoma". Invited plenary speaker on "Modern developments in cancer therapeutics." American Association for Cancer Research , Academia Sinica, Taipei, Taiwan. 1996 "Application of intracellular sorting signals in the development of cancer vaccines." Invited speaker, Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, Maryland. 1996 "Vaccinia vaccine vectors for cervical cancer." Invited speaker, Human Genetics Program, The Johns Hopkins University, School of Medicine, Baltimore, Maryland. 1996 "Antigen specific cancer immunotherapy for HPV-associated cervical cancers." Immunology Council, The Johns Hopkins University, Baltimore, Maryland. 1996 "Development of antigen specific cancer vaccines using intracellular sorting signals." Invited speaker, 15th International Papillomavirus Workshop, Brisbane, Australia. 1997 "Development of Vaccines and immunotherapeutic strategies for HPV-related cervical Cancer." Chlamydia/STD Seminar Series. The Johns Hopkins Hospital, Baltimore, Maryland. 1997 "Novel Strategy for Antigen Specific Cancer Immunotherapy." Invited speaker, Department of Molecular Microbiology and Immunology. The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland. 1997 "Vaccine and Immunotherapeutic strategies for HPV-associated neoplasms." Invited speaker, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 1997 "Antigen specific cancer immunotherapy." Invited speaker, Department of Microbiology and Immunology, Loyola University, Chicago 1997 "Development of vaccines and immunotherapeutic strategies for HPV-associated cervical cancers." Invited plenary speaker, 1st Annual Terry Fox and Chang-Gung Memorial Hospital International Cancer Symposium on Cervical Cancer, Taipei, Taiwan 1998 "Cervical Cancer and HPV vaccines." Invited speaker, Department of Pathology, Medical College of Virginia, Richmond. 1998 "Antigen targeting to the MHC processing pathway." Invited plenary speaker, 1st Annual Meeting of The American Society of Gene Therapy, Seattle, Washington 1999 "Cancer immunotherapy for HPV-associated cervical cancers." Invited speaker, National Cancer Institute, National Institutes of Health, Baltimore, Maryland. 2000 “Development of preventive and therapeutic vaccines for HPV-associated cancers.” Plenary speaker, American Association for Cancer Research, 91st Annual Meeting, San Francisco. 2000 “Development of vaccines and immunotherapeutic strategies for HPV-associated cervical cancers." Invited keynote speaker, The Joint Symposium of Oncology Research of Taiwan, Taipei, Taiwan. 2000 “Development of vaccines for HPV-associated cervical cancers." Invited speaker, Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida. 2001 “Preclinical model for cervical carcinogenesis.” Invited plenary speaker,1st International Conference on Cervical Cancer, Baltimore, Maryland. 2001 “Development of cervical cancer vaccines.” Invited plenary speaker, the American Cancer Society's 43rd Annual Science Writers Seminar, Dana Point, California. 2001 “ Novel strategies to enhance nucleic acid vaccine potency.” Invited speaker, Ohio State University School of Medicine, Columbus, Ohio. 2001 “Preventive and therapeutic approaches toward HPV-associated neoplasia.” Invited plenary speaker, HPV- 2001 meeting, Taipei, Taiwan, R.O.C. 2001 “Development of vaccine and Immunotherapeutic strategies for HPV-associated cervical cancers.” Invited speaker, 21st Annual Resident’s Research Day, Lenox Hill Hospital, New York. 2001 “Vaccines and immunotherapeutic strategies for cancers.” Invited speaker, Department of Molecular & Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY. 2001 “Preclinical model for cervical cancer.” Invited speaker, NIH/NCI Roundtable Discussion for Gynecological Cancer, Washington, DC. 2002 “Innovative DNA Vaccines for HPV-Associated Malignancies.” Invited speaker, NIH/NCI RAID Program, Frederick, MD. 2002 “ Development of Innovative DNA Vaccines for the Control of Cancers.” Invited plenary speaker, 1st Taiwan- America Biotech Conference & Exhibition, San Diego, CA. 2002 “Improving DNA Vaccine Potency Through Intracellular and Intercellular Targeting Strategies.” Invited speaker, Hematopoeisis/Immunology Society, Department of Oncology, The Johns Hopkins University, Baltimore, MD. 2002 “Strategies to enhance DNA vaccine potency.” Invited plenary speaker, 2002 Advances in Designing Cancer Vaccines, Boston, MA. 2002 “DNA vaccines for cancer.” Invited speaker, The EORTC-AACR 2002 symposium on “Molecular Targets and Cancer Therapeutics”, Frankfurt, Germany. 2002 “Development of Innovative DNA Vaccines for Cervical Cancer.” Invited plenary speaker, 2nd International Conference on Cervical Cancer, MD Anderson, Houston, Texas. 2002 “Development of innovative strategies to enhance DNA vaccine potency.” Invited Speaker, Education Section for Transgene Immunology, 5th Annual Meeting of the American Society of Gene Therapy, Boston, MA 2002 “ Immunotherapy for Gynecologic Malignancies.” Invited plenary speaker, The Satellite Symposium “Management of recurrent gynecologic malignancies” for the 9th Biennial Meeting of the International Gynecologic Cancer Society, Taipei, Taiwan. 2002 “DNA Vaccines for Cancer.” Invited speaker, Surgery Branch of the National Cancer Institute, Washington, DC 2002 “Development of Cell mediated immunological Assays for HPV.” Invited speaker, DAIT Immunology Centers Meeting, NIAID/NIH, Washington, DC 2002 “Development of Vaccines and Immunotherapeutic Strategies for HPV-associated Cancers.” Invited speaker, Wayne State University Karmanos Cancer Institute, Detroit, MI. 2002 “Development of Vaccines and Immunotherapeutic Strategies for HPV-associated Cervical Cancers.” Invited Speaker, Grand Round of USC Cancer Center, USC, Los Angeles, CA 2003 “DNA Vaccines for Antigen-Specific Cancer Immunotherapy” Invited Speaker, Department of Immunology, Mayo Clinic and Mayo Graduate School, Rochester, MN. 2003 “Improving DNA Vaccine Potency via Modification of Professional Antigen Presenting Cells” Invited Speaker, the 5th Annual Walker’s Cay Colloquium on Cancer Vaccines and Immunotherapy, Walker’s Cay, Bahamas. 2003 “DNA Vaccines for Cancer Immunotherapy” Invited Speaker, Basic Science Seminar, Oncology Center, Loyola University, Chicago 2003 “DNA Vaccines for HPV-Associated Malignancies: from Bench to Bed Side” Invited Speaker, The 27th Clinical Research Seminar, Department of Health, Taiwan 2003 “Development of HPV DNA vaccines for AIDS patients” Invited Speaker, the Seventh International Conference of Malignancies in AIDS and Other Immunodeficiencies: Basic, Epidemiologic and Clinical Research., Washington, DC. 2003 “Antigen processing and Therapeutic Vaccines” Invited Speaker, Women’s Interagency HIV Study mini symposium, Washington, DC. 2003 “Development of Innovative DNA Vaccines against SARS” Invited Speaker, DAIT Biodefense Meeting, NIAID/NIH, Washington, DC. 2003 “DNA Vaccines for Cancers” Invited Speaker, Pediatric AIDS Clinical Trials Group Meeting, NIAID/NIH, Washington, DC. 2004 “DNA vaccines for HPV-Associated Cancers” Invited Speaker, Grand Round, Department of Dermatology, The Johns Hopkins University, Baltimore, MD. Invited Reviews, Editorials: 1) T.-C. Wu. (1994) Immunology of Human Papilloma Virus (in relation to cancer). Current Opinion in Immunology. 6:728-732. 2) T.-C. Wu and Robert J. Kurman. (1997) Analysis of cytokine profiles in patients with HPV-associated neoplasms. J. Natl Cancer Inst. 89: 185-187. 3) C.-H. Chen and T.-C. Wu (1998) Experimental vaccine strategies for cancer immunotherapy. J. Biomedical Science 5: 231-252. 4) M. Ling, M. Kanayama, R. Roden and T.-C. Wu (2000) Preventive and therapeutic vaccines for HPV-associated cervical cancers. J. Biomedical Science 7: 341-356. 5) M. Moniz, M. Ling, C.-H. Hung and T.-C. Wu (2003) HPV DNA Vaccines. Frontiers in Bioscience 8:55-68. 6) C.-F. Hung and T.-C. Wu (2003) Improving DNA vaccine potency via modification of professional antigen presenting cells. Current Opinion in Molecular Therapeutics 5: 20-24. 7) K. Devaraj, M.L. Gillison and T.-C. Wu (2003) Development of HPV vaccines for HPV-associated head and neck squamous cell carcinoma. Critical Reviews in Oral Biology & Medicine 14: 345-362. 8) T.-C. Wu and D. Boyd (2003) Commentary on a controlled trial of a human papillomavirus type 16 vaccine Evidence Based Obstetrics & Gynecology (in press). 9) R. Roden and T.-C. Wu (2003) Preventive and therapeutic vaccines for cervical cancer. Expert Review of Vaccines. 2: 495-516. 10) D. Boyd, C.-F. Hung and T.-C. Wu (2003) DNA vaccines for Cancer. IDrugs 6: 1155-1164. 11) M. Moniz, J. Yeatermeyer, and T.-C. Wu (2004) Control of cancers by combining antiangiogenesis and cancer immunotherapy Drugs of Today (in press) 12) R. Roden, Morris Ling and T.-C. Wu (2004) HPV Vaccines Human Pathology (in press). OTHER PROFESSIONAL ACCOMPLISHMENTS January 1998- January 1999 President of the Society of Chinese Bioscientists in America (SCBA), DC Chapter January 2000-January 2001 Secretary-Treasurer of International Association of Chinese Pathologists January 2001-January 2003 President-Elect of International Association of Chinese Pathologists January 2003-present President of International Association of Chinese Pathologists |