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Tissue/Pathology Core C
Organized collection and expert pathologic evaluation of human
tissues and biologic fluids is pivotal to the translational mission
of this SPORE project. Thus this Tissue/Pathology Core is
designed to provide well-characterized human biological specimens to
researchers participating in the Johns Hopkins Cervical Cancer SPORE
and other similar research efforts.
In addition to
the growing need for sophisticated sample acquisition, investigators
increasingly depend on Pathology support to ensure proper tissue
preparation and characterization for selected studies.
This Core will also provide expert pathologic evaluation of
specimens and technical support.
Specifically, this
core will: 1. Obtain written informed consent and collect specimens
from patients for translational research without compromise of
patient care or confidentiality, 2. Collect cervical carcinoma and
pre-malignant lesions, as well as normal tissue, 3. Provide normal
control tissue in addition to neoplasms whenever possible, 4.
Process and store tissues to address the requirements of all SPORE
investigators, 5. Support the development and implementation of
immunologic assays, 6. Collect blood, secretions and exfoliated
cells (e.g. cervical scrapes) from patients, including those
enrolled in clinical trials for the SPORE projects, 7. Provide
specimens that are well-characterized with respect to site of
origin, pathologic grading and staging, and proportion of neoplastic
and stromal tissue, 8. Provide quality-controlled specimens in a
timely fashion as inexpensively and efficiently as possible, 9. Use
well-defined mechanisms for prioritization of the distribution of
requested specimens to investigators within and external to the
Johns Hopkins SPORE, 10. Route specimens for virologic analyses
(e.g. HPV testing and typing), immunophenotyping (e.g.HLA typing),
EBV-immortalization, microarray or laser-capture microdissection in
fee per service facilities. The samples are tracked using a
password-protected Filemaker Pro relational database that will be
web enabled for access by our off-site projects. The
activities of the Resource Core will be integrated with those of the
Administrative/Clinical Core and the Biostatistics and
Bioinformatics Core to ensure that specimens and clinical
information are appropriately catalogued and disseminated.
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