Richard B.S. Roden, Ph.D.

Principal investigator, Project 3

Co-Investigator, Project 4

Education/Training

University of Bristol, Bristol, England.

B.Sc. Hons (Biochemistry), 1988

University of Cambridge, Cambridge, England.

Ph.D. (Biochemistry), 1992

National Cancer Institute, Bethesda, MD.

Visiting Fellow, 1992-1997

Professional Experience

Selected Publications
Roden, R.B., Y. Shachar-Hill, S.C. Cosulich, T.R. Hesketh, and J.C. Metcalfe. A common requirement for p21c-ras function in the mitogenic signaling pathways of Swiss 3T3 fibroblasts. Cell Growth Differ, 1993. 4(12): p. 957-64.

Kirnbauer, R., J. Taub, H. Greenstone, R. Roden, M. Durst, L. Gissmann, D.R. Lowy, and J.T. Schiller. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J Virol, 1993. 67(12): p. 6929-36.

Roden, R.B., R. Kirnbauer, A.B. Jenson, D.R. Lowy, and J.T. Schiller. Interaction of papillomaviruses with the cell surface. J Virol, 1994. 68(11): p. 7260-6.

Roden, R.B., E.M. Weissinger, D.W. Henderson, F. Booy, R. Kirnbauer, J.F. Mushinski, D.R. Lowy, and J.T. Schiller. Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins. J Virol, 1994. 68(11): p. 7570-4.

Roden, R.B., N.L. Hubbert, R. Kirnbauer, F. Breitburd, D.R. Lowy, and J.T. Schiller. Papillomavirus L1 capsids agglutinate mouse erythrocytes through a proteinaceous receptor. J Virol, 1995. 69(8): p. 5147-51.

Roden, R.B., H.L. Greenstone, R. Kirnbauer, F.P. Booy, J. Jessie, D.R. Lowy, and J.T. Schiller. In vitro generation and type-specific neutralization of a human papillomavirus type 16 virion pseudotype. J Virol, 1996. 70(9): p. 5875-83.

Roden, R.B., N.L. Hubbert, R. Kirnbauer, N.D. Christensen, D.R. Lowy, and J.T. Schiller, Assessment of the serological relatedness of genital human papillomaviruses by hemagglutination inhibition. J Virol, 1996. 70(5): p. 3298-301.

Roden, R.B., D.R. Lowy, and J.T. Schiller. Papillomavirus is resistant to desiccation. J Infect Dis, 1997. 176(4): p. 1076-9.

Nardelli-Haefliger, D., R.B. Roden, J. Benyacoub, R. Sahli, J.P. Kraehenbuhl, J.T. Schiller, P. Lachat, A. Potts, and P. De Grandi. Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice. Infect Immun, 1997. 65(8): p. 3328-36.

Roden, R.B., A. Armstrong, P. Haderer, N.D. Christensen, N.L. Hubbert, D.R. Lowy, J.T. Schiller, and R. Kirnbauer. Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope. J Virol, 1997. 71(8): p. 6247-52.

Trus, B.L., R.B. Roden, H.L. Greenstone, M. Vrhel, J.T. Schiller, and F.P. Booy. Novel structural features of bovine papillomavirus capsid revealed by a three-dimensional reconstruction to 9 A resolution. Nat Struct Biol, 1997. 4(5): p. 413-20.

Balmelli, C., R. Roden, A. Potts, J. Schiller, P. De Grandi, and D. Nardelli-Haefliger. Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions. J Virol, 1998. 72(10): p. 8220-9.

Booy, F.P., R.B. Roden, H.L. Greenstone, J.T. Schiller, and B.L. Trus. Two antibodies that neutralize papillomavirus by different mechanisms show distinct binding patterns at 13 A resolution. J Mol Biol, 1998. 281(1): p. 95-106.

Greenstone, H.L., J.D. Nieland, K.E. de Visser, M.L. De Bruijn, R. Kirnbauer, R.B. Roden, D.R. Lowy, W.M. Kast, and J.T. Schiller. Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model. Proc Natl Acad Sci U S A, 1998. 95(4): p. 1800-5.

Day, P.M., R.B. Roden, D.R. Lowy, and J.T. Schiller. The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domains. J Virol, 1998. 72(1): p. 142-50.

Nardelli-Haefliger, D, RBS Roden, C Balmelli, A Potts, JT Schiller, and P De Grandi. Nasal but not parenteral immunization with purified human papillomavirus type 16 virus like particles induces neutralizing titers of antibodies throughout the estrous cycle of mice. J. Virol, 1999. 73 9609-9613.

Roden, RBS, WH Yutzy, S Inglis, DR Lowy, and JT Schiller. Minor capsid protein of human genital papillomaviruses contains sub-dominant, cross-neutralizing epitopes. Virology, 2000. 270 254-257.

Ling, M, Kanayama, M, Roden, RBS and T-C Wu. Preventative and therapeutic vaccines for HPV-associated cervical cancers. J. Biomed. Sci. 7 341-356

Harro, C, Pang, S, Roden, RBS, Hildesheim, A, Wang, W, Robinson, R, Murphy, BR, Karron, R, Dilner, J, Schiller, T, and DR Lowy. A Safety and Immunogenicity trial of a Human Papillomavirus type 16 L1 Virus-like particle vaccine in healthy young adult human volunteers. J. Natl. Cancer Inst. (2001) 93:284-292

Cheng, W-F, Hung, C-F, Hsu, K-F, Chai, C-Y, He, L, Slater, LA, Rice, CM, Roden, RBS, and T-C Wu. Enhancement of Sindbis Virus Self-replicating RNA vaccine potency by targeting antigen to endosomal/lysosomal compartments. Human Gene Therapy (2001) 12:235-252

Okun, MM, Day, PM, FP Booy, DR Lowy Schiller, JT and RBS Roden. Interaction between the Minor Papillomavirus Capsid Protein, L2, and the Major Papillomavirus Capsid Protein, L1. J. Virology (2001) 75:4332-4342

Naora, H, Yang, Y, Montz, FJ, Seidman, JD, Kurman, RJ, and RBS Roden. A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells. Proc. Natl. Acad. Sci. USA (2001) 98:4060-4065

Roden, RBS, Day, PM, Bronzo, BK, Lowy, DR, and JT Schiller. Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection. (J. Virol, in press)

Naora, H, Montz, FJ, Chai, C-Y, and RBS Roden. The homeobox gene HOXA7 encodes an autoantigen associated with aberrant mullerian differentiation in epithelial ovarian neoplasia. (submitted)