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Hypophysis Hypophysitis Autoimmune Hypophysitis Diagnosis & Treatment Research

Historical Notes
Typical Clinical Scenarios

Autoimmune hypophysitis is a chronic inflammation of the pituitary gland caused by autoimmunity. This disease is most commonly known in the literature as lymphocytic hypophysitis, although the term "lymphocytic" is imprecise. After the original description (see below), the disease was called, more precisely, "lymphocytic adenohypophysitis" because the lymphocytic infiltration was limited to the anterior hypophysis. It was then realized that the autoimmune attack could also and exclusively involve the infundibular stem and the posterior lobe, and so the term "lymphocytic infundibulo-neurohypophysitis" was created. Finally it was realized that the lymphocytic infiltration can affect both the adenoyhypophysis and the infunbibulo-neurohypophysis and so the term "lymphocytic infundibulo-hypophysitis" arose. We prefer the simpler term autoimmune hypophysitis, followed by the specific anatomic location when known (anterior, posterior or both).


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