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Patient ID Duration of symptoms (months) Description of symptoms Headache at presentation Visual disturbances at presentation Low ACTH symptoms at presentation Low TSH symptoms at presentation Low PRL symptoms at presentation Low gonadotropin symptoms at presentation Low ADH symptoms at presentation High PRL symptoms at presentation Incidentaloma
1 12 2 days history of severe lower abdominal pain, vomiting, diarrhea. An acutely inflamed, but not ruptured, appendix was removed. 8 hours after the operation she developed peripheral circulatory failure and died. No No No Yes No No No No No
2 1 3 years history of pernicious anemia. 3 weeks history of drowsiness and mental confusion. She was found unconscious at home and brought to the hospital, where she died 5 days later. No No Yes No No No No No No
3 6 Fatigue, weight loss, sleepiness. Menses did not return after delivery. Then 4 days before hospitalization, she developed nausea, vomiting, diarrhea, chills and fever. On admission she was comatose. 19 days after admission she developed hypoglycemic coma, disoriented, dried skin. IV glucose given, but subsequent coma on day 23. Extracts of adrenal cortex were given but she died the next day. No No Yes No No No No Yes No
4 6 6 months history of cold intolerance and pallor; 3 months history of dizziness and headaches. Yes No Yes Yes No No No No No
5 0 10 days history of polyuria and dehydration without polydipsia. Patient had iatrogenic Cushing due to 6 years administration of steroid for asthma. She was severely dehydrated. She began Pitressin Tannate with a striking response. Two months after discharge, however, she had a severe attack of bronchial asthma and died. No No No No No No Yes No No
6 24 2 years history of fatigue and anemia; 2 months history of nausea, vomiting, diarrhea, weight loss. No No Yes No No No No No No
7 60 5 years history of hypopituitarism. He then developed hypotension, hypoglycemic coma, fever and died No No Yes No No No No No No
8 3 3 months history of fatigue, nausea and weight loss. Then confusion and semicomatose state. Finally hypoglycemic coma and death. No No Yes No No No No No No
9 8 years history of Addison's disease No No Yes No No No No No No
10 Headache and visual field defects. Then, fatigue, anorexia, nausea, weight loss Yes Yes Yes No No No No No No
11 Headache, amenorrhea, galactorrhea Yes No No No No No No Yes No
12 generalized muscle weakness, then anorexia, abdominal pain, hypoglycemia No No Yes No No No No No No
13 Visual field defects. No Yes No No No No No No No
14 Headaches, nausea, vomiting. Then, after delivery, amenorrhea and inability to lactate, no growth of axillary hair. Yes No Yes No Yes No No Yes No
15 14 Headache. Then 14 months after delivery she noticed milk discharging from her nipples and thought she was pregnant. She committed suicide. Yes No No No No No No Yes No
16 Headache starting during the last month of pregnancy. Yes No No No No No No No No
17 visual field defects No Yes No No No No No No No
18 visual field defects & headaches Yes Yes No No No No No No No
19 headache and visual field defects Yes Yes No No No No No No No
20 Weakness, anorexia and orthostatic dizziness No No Yes No No No No No No
21 Headache and fatigue in the last trimester of her second pregnancy (the first ended with a spontaneous abortion). After delivery, headaches disappeared, but fatigue increased. 7 months after delivery, she complained of amenorrhea, loss of libido, loss of pubic and axillary hair Yes No Yes No No Yes No Yes No
22 36 3 years course of progressive hypopituitarism and bulimia, with mild hyperprolactinemia. 3 days coma after gallbladder surgery then she died unexpectedly No No Yes No No No No Yes No
23 Headache then visual field defects Yes Yes No No No No No No No
24 Unable to lactate, fatigue, dry skin, hoarse voice, decreased axillary and pubic hair No No Yes Yes Yes No No No No
25 36 3 years history of amenorrhea (evaluated for infertility), 1 month history of orthostatic dizziness and primary hypothyroidism, 3 days history of headache, anorexia, nausea and abdominal pain. She then became lethargic and was admitted to the emergency room Yes No Yes No No No No Yes No
26 Inability to lactate, amenorrhea, fatigue, low blood pressure. Then mental confusion, circulatory shock and death No No Yes No Yes No No Yes No
27 weakness, weight loss, headache. Then amenorrhea, inability to lactate, hair loss. After 2 months in the hospital the patient became comatose and died. Yes No Yes No Yes No No Yes No
28 24 24 months history of hypoglycemic crisis, fatigue, hypotension, loss of hair. She was unable to lactate after delivery, menses returned but not every month. No No Yes No Yes No No Yes No
29 18 18 months history of amenorrhea, fatigue, hypotension, loss of hair, hypoglycemic crisis. After her second delivery she was able to lactate but menses did not return No No Yes No Yes No No Yes No
30 Dizziness and blurred vision during labor. During labor she developed circulatory shock, went into deep coma and died. The baby could not be saved. No Yes No No No No No No No
31 Weakness, anorexia, nausea, vomiting, weight loss No No Yes No No No No No No
32 Headaches, weakness and vomiting Yes No Yes No No No No No No
33 10 No menses after 2nd delivery. Then over the next months fatigue. 10 months after delivery, sudden headache Yes No Yes No No No No Yes No
34 Headache, vomiting and visual field defects Yes Yes No No No No No No No
35 Fatigue, orthostatic dizziness, nausea, vomiting, mild visual field defects No Yes Yes No No No No No No
36 Headache and visual field defects. The labor was OK but she was unable to lactate Yes Yes No No Yes No No No No
37 Secondary amenorrhea. She took contraceptive pill from age 21 to 28. At that time she developed hyperprolactenemia and became amenorrhoic, so she was treated with bromocriptine. No No No No No No No Yes No
38 Headaches, visual field defects Yes Yes No No No No No No No
39 visual field defects. She delivered uneventfully a health infant. After delivery she was unable to lactate and developed hypotension and pallor No Yes Yes No Yes No No No No
40 After delivery, she was unable to lactate and menses did not return (amenorrhea). She then developed fatigue, weight loss, cold intolerance, and loss of axillary and pubic hair. She came to medical attention approximately 1.5 years after delivery. No No Yes Yes Yes No No Yes No
41 Impotence, fatigue, weight loss, decreased beard growth, constipation, intolerance to cold No No Yes Yes No Yes No No No
42 Headache and visual field defects. Then fatigue and low blood pressure. No lactation was evident after delivery. Yes Yes Yes No Yes No No No No
43 Visual field disturbances. No Yes No No No No No No No
44 Headache and visual field defects Yes Yes No No No No No No No
45 6 Headache, photophobia and vomiting. Lymphocytosis in the CSF, no pathogens. Symptoms resolved spontaneously. 4 months later: weakness, cold intolerance. Yes No Yes Yes No No No No No
46 Headaches (began near delivery then intensified), then fatigue, vomiting, weight loss, dizziness Yes No Yes No No No No No No
47 1 1 month history of headaches and visual field defects, increasing toward the end of pregnancy and worsened 3 days after delivery. Patient was unable to lactate so she was hospitalized. Yes Yes No No Yes No No No No
48 Headache and visual field defects Yes Yes No No No No No No No
49 Headache and blurring of vision Yes Yes No No No No No No No
50 Headache, fatigue, decreased libido, amenorrhea, polyuria and polydipsia Yes No Yes No No Yes Yes Yes No
51 Cold intolerance and general weakness No No Yes Yes No No No No No
52 Progressive visual disturbances. Inability to lactate. No Yes No No Yes No No No No
53 4 4 months history of headaches and amenorrhea, inability to lactate Yes No No No Yes No No Yes No
54 8 8 months history of galactorrhea and amenorrhea, 2 months history of headaches, visual field defects and weight loss Yes Yes No No No No No Yes No
55 Severe headache, weakens, anorexia, hypotension Yes No Yes No No No No No No
56 2 Headache and visual field defects. Then she presented 2 months after delivery with loss of vision in the left eye. She was unable to lactate. Yes Yes No No Yes No No No No
57 Headache and blurring of vision. After delivery she was unable to lactate. Then she developed fatigue and orthostatic dizziness. Yes Yes Yes No Yes No No No No
58 6 Unable to lactate after the 1st delivery. Then fatigue. She became pregnant 1 year after the first delivery. Throughout the 2nd pregnancy she was fatigued, anorexic and with orthostatic dizziness. Headache began in the 2nd month. After the 2nd delivery, she did not lactate, menses did not return and headaches continued. She also complained of decreased libido, decreased axillary and pubic hair, polydipsia and polyuria. Yes No Yes Yes Yes Yes Yes Yes No
59 4 4 months history of polyuria, polydipsia, and anorexia. Then dehydration and disturbances of consciousness. Patient died of bronchopneumonia No No No No No No Yes No No
60 Polyuria, polydipsia, fatigue, anorexia, visual field defects No Yes Yes No No No Yes No No
61 Amenorrhea, later accompanied by headache, nausea and vomiting Yes No Yes No No No No Yes No
62 36 3 years history of amenorrhea No No No No No No No Yes No
63 Visual field and acuity defects No Yes No No No No No No No
64 Headaches, fever and visual field defects Yes Yes No No No No No No No
65 Headache and visual field defects Yes Yes No No No No No No No
66 Postural hypotension; long history of fatigue, loss of concentration and decreased libido and potency No No Yes Yes No Yes No No No
67 Headaches, visual field defects, polydipsia. Yes Yes No No No No Yes No No
68 1 1 month history of headaches and visual field defects and 2 months history of amenorrhea Yes Yes No No No No No Yes No
69 Headache and visual field defects Yes Yes No No No No No No No
70 Headache and visual field defects Yes Yes No No No No No No No
71 visual field defects No Yes No No No No No No No
72 Visual field defects No Yes No No No No No No No
73 Headache, visual field defects, and fatigue Yes Yes Yes No No No No No No
74 9 9 months history of amenorrhea and galactorrhea No No No No No No No Yes No
75 Infertility. She also complained of mild galactorrhea and headaches. PRL was 93 ng/ml. Yes No No No No Yes No Yes No
76 3 Headaches, impotence, polyuria and polydipsia for 3 months Yes No No No No Yes Yes No No
77 Headache, polydipsia and polyuria, then amenorrhea Yes No No No No No Yes Yes No
78 headaches, vomiting, polyuria, polydipsia. Then fatigue, amenorrhea, decreased libido. Visual field defects Yes Yes Yes No No Yes Yes Yes No
79 12 Two years history of high blood pressure, 1 year history of amenorrhea, 1 month history of visual field defects No Yes No No No No No Yes No
80 0 10 days history of visual field defects and headaches. Clinically there was no evidence of hypopituitarism Yes Yes No No No No No No No
81 visual field defects. Delivery was performed at the 39th week by caesarian section. No Yes No No No No No No No
82 visual field defects and headaches. She delivered uneventfully at 40 weeks Yes Yes No No No No No No No
83 4 4 months history of polyuria, polydipsia and thirst. She began 2 months later desmopressin replacement No No No No No No Yes No No
84 4 In the 4th month of pregnancy she had a threatened abortion. In the 5ht month she developed headache, in the 7th visual defects and in the 8th bitemporal hemianopsia Yes Yes No No No No No No No
85 6 6 month history of headache and fever. Borderline polyuria. She was hospitalized. Yes No No No No No Yes No No
86 6 Three months after her 2nd delivery she noted loss of axillary hair. Then at 4 month developed symptoms of thyrotoxicosis, which resolved in 1 month. She then developed mild hypothyroidism with inappropriately low TSH. For this reason a pituitary dysfunction was suspected. 9 months post-partum, endocrine testing showed a secondary hypocortisolism No No Yes Yes No No No No No
87 Polyuria, vomiting, sudden death probably secondary to marked dehydration. The patient lived in a home for mentally retarded. No No No No No No Yes No No
88 polyuria and polydipsia No No No No No No Yes No No
89 headaches, visual field defects Yes Yes No No No No No No No
90 Headaches, diplopia. Then fatigue, decreased libido and potency Yes Yes Yes No No Yes No No No
91 Acute onset of polyuria and polydipsia No No No No No No Yes No No
92 Acute onset of polyuria and polydipsia No No No No No No Yes No No
93 Acute onset of polyuria and polydipsia No No No No No No Yes No No
94 headaches, fatigue Yes No Yes No No No No No No
95 Fainting No No Yes No No No No No No
96 4 Headaches and amenorrhea of 4 months duration. Then polyuria, nocturia, polydipsia with a preference for cold fluids Yes No No No No No Yes Yes No
97 Weight loss from painless thyroiditis and fatigue No No Yes No No No No No No
98 5 5 months history of polyuria and polydipsia, 1 month history of visual field defects No Yes No No No No Yes No No
99 2 2 months history of polyuria and polydipsia No No No No No No Yes No No
100 After her 3rd delivery, at age 26, she was unable to lactate and became oligomenorrhoic. Then, in her mid thirties, she became amenorrhoic and remained so. Then she developed gradual loss of pubic and axillary hair, then fatigue, coarse voice and facial and hand puffiness No No Yes Yes Yes No No Yes No
101 polyuria, headaches and photophobia Yes No No No No No Yes No No
102 12 12 months history of visual field defects No Yes No No No No No No No
103 polyuria, thirst and polydipsia No No No No No No Yes No No
104 visual disturbances, polyuria and polydipsia No Yes No No No No Yes No No
105 4 4 months history of amenorrhea, headaches and vomiting Yes No No No No No No Yes No
106 headache, polyuria, polydipsia, impotence, and cold intolerance Yes No No Yes No Yes Yes No No
107 0 1-week history of polyuria and polydipsia. He began desmopressin. Over the next 6 months he developed symptoms of hypogonadism and hypothyroidism. No No No Yes No Yes Yes No No
108 Headache Yes No No No No No No No No
109 Recent onset of headache, polydipsia and polyuria. Water deprivation test and pitressin test showed central diabetes insipidus Yes No No No No No Yes No No
110 Headache, lethargy, reduced libido, cold intolerance, failure to ejaculate Yes No No Yes No Yes No No No
111 Headache, lethargy, reduced libido, polydipsia and polyuria Yes No No No No Yes Yes No No
112 Headache, visual field defects, impaired ability to lactate Yes Yes No No Yes No No No No
113 Headache, vomiting and diplopia Yes Yes Yes No No No No No No
114 Headache Yes No No No No No No No No
115 Amenorrhea, polyuria and polydipsia, cold intolerance, orthostatic hypotension No No Yes Yes No No Yes Yes No
116 Headache, polyuria, polydipsia. She also had a long history of pustolosis palmaris and plantaris. Yes No No No No No Yes No No
117 fatigue, vomiting, weight loss and inability to lactate No No Yes No Yes No No No No
118 0 36 hours history of nausea, vomiting, mild abdominal discomfort. He was brought to the emergency room because of a 45 min loss of consciousness. The patient had no previous history of hypocortisolism, hypothyroidism or other hormone deficiencies. No No Yes No No No No No No
119 3 headaches and vomiting. Then, 2 months later, visual field defects Yes Yes No No No No No No No
120 25 2 years history of secondary amenorrhea, decreased libido and hair loss. Then she was discovered by her husband in convulsions and brought to the emergency room, but she died 5.5 hours later (severe hypoglycemia) No No No No No Yes No Yes No
121 acute development of thirst, polydipsia, polyuria. She was able to breast-feed normally but her menses had not returned at the time of presentation No No No No No No Yes Yes No
122 5 fatigue, lethargy, hair loss. Then, 5 months after delivery, she developed orthostatic hypotension, muscle cramps, profound weakness, lack of lactation. Menses had not returned. No No Yes Yes No No No No No
123 2 2 months history of polydipsia and polyuria diagnosed as diabetes insipidus and treated with desmopressin. No visual defects No No No No No No Yes No No
124 Fatigue, impotence, polyuria and polydipsia No No Yes No No Yes Yes No No
125 Headache, amenorrhea, galactorrhea Yes No No No No No No Yes No
126 Headache, decreased libido, visual field defects Yes Yes No No No Yes No No No
127 Headache, diplopia, palsy of the 6th cranial nerve Yes Yes No No No No No No No
128 Headache Yes No No No No No No No No
129 Headache, visual field defects, oligomenorrhea Yes Yes No No No No No Yes No
130 Headache, blurred vision, cold intolerance, nocturnal hot flashes, weight loss, anorexia Yes Yes Yes Yes No No No No No
131 18 18 months history of fatigue and weight gain despite dieting, 12 months history of headaches, 4 months history of amenorrhea. After delivery, which occurred 18 months before presentation, she breast-fed for 6 months but then had persistent galactorrhea; menses returned post-partum but ceased suddenly. Yes No No Yes No No No Yes No
132 Headaches, then cold intolerance Yes No No Yes No No No No No
133 Headache Yes No No No No No No No No
134 Secondary amenorrhea No No No No No No No Yes No
136 12 Headache. She gave a history of 1 year amenorrhea and 1 month galactorrhea Yes No No No No No No Yes No
137 11 Myalgia and joint stiffness, fatigue, unable to lactate. Menses had not returned 11 months after delivery No No Yes No Yes No No Yes No
138 fatigue, neck pain, hair loss, dry hair, unable to lactate No No Yes Yes Yes No No No No
139 Visual field defects. Then unable to lactate and amenorrhoic No Yes No No Yes No No Yes No
140 Headache, visual filed defects Yes Yes No No No No No No No
141 lethargy and anorexia. Then weight loss. No No Yes No No No No No No
142 Headaches, anorexia, nausea, vomiting, inability to breast feed, visual field defects Yes Yes Yes No No No No No No
143 Headache, visual field defects, vomiting Yes Yes No No No No No No No
144 Headache and visual field defects Yes Yes No No No No No No No
145 Headaches, hypopituitarism, polyuria and polydipsia Yes No Yes Yes No No Yes No No
146 Visual field defects, hyperprolactenemia, polyuria and polydipsia No Yes No No No No Yes Yes No
147 post-partum thyrotoxicosis No No No No No No No No No
148 Panhypopituitarism, increased calcemia No No Yes Yes No Yes No No No
149 Panhypopituitarism No No Yes Yes No Yes No No No
150 Hypopituitarism No No Yes Yes No No No No No
151 Headaches, visual filed defects Yes Yes No No No No No No No
152 Headaches, visual filed defects Yes Yes No No No No No No No
153 Amenorrhea No No No No No No No Yes No
154 Visual field defects, hyperprolactenemia No Yes No No No No No Yes No
155 Visual field defects, diabetes insipidus, hyperprolactenemia No Yes No No No No No Yes No
156 12 12 months history of headaches, dizziness, and episodes of diplopia Yes Yes No No No No No No No
157 2 Visual disturbances in her left eye. One month after delivery, she suffered from fever, chest pain and dyspnea and was admitted to the hospital with a diagnosis of pericarditis/myocarditis. 1 month later, because of slowly progressive visual disturbances, she was referred to neurosurgery. No Yes No No No No No No No
158 72 At age 8 history of polyuria, polydipsia diagnosed as diabetes insipidus. He began desmopressin replacement. At age 10, short stature and hypopituitarism by endocrine testing. He began thyroxine and GH replacement. At age 14 delayed puberty. No No No No No No Yes No No
159 4 4 months history of headache, nausea and fever. Meningitis was suspected. 1 month history of polyuria, thirst, anorexia, impotence and hair loss Yes No No Yes No Yes Yes No No
160 1 1 month history of polyuria and thirst No No No No No No Yes No No
161 Headaches, myalgias, fatigue, weight gain Yes No Yes Yes No No No No No
162 Fatigue, myalgia, amenorrhea, inability to lactate No No Yes No Yes No No Yes No
163 Headache, polyuria, polydipsia, fatigue, anorexia, weight loss Yes No Yes No No No Yes No No
164 polyuria, polydipsia No No No No No No Yes No No
165 polyuria and polydipsia No No No No No No Yes No No
166 Headaches, visual field defects. Lactation ceased abruptly after 4 months and menses did not recur. Yes Yes No No Yes No No Yes No
167 polyuria and polydipsia No No No No No No Yes No No
168 Visual field defects and headaches. Then, after delivery, inability to lactate Yes Yes No No Yes No No No No
169 Menses did not return post-partum, then she developed fatigue, orthostatic hypotension and abdominal pain. No No Yes No No No No Yes No
170 Headaches and visual field defects. Patient delivered a term infant. Then 7 months post-partum she complains again of headaches Yes Yes No No No No No No No
171 vomiting and diarrhea No No Yes No No No No No No
172 Headaches and vomiting, which worsened after delivery. Inability to lactate. Yes No No No Yes No No No No
173 24 2 years history of headaches, 1 year history of amenorrhea, orthostatic hypotension, clinically hypothyroid Yes No Yes No No No No Yes No
174 Visual field defect No Yes No No No No No No No
175 Headaches and visual field defects Yes Yes No No No No No No No
176 4 4 months history of polyuria and polydipsia No No No No No No Yes No No
177 2 2 months history of thirst, polydipsia, polyuria, anorexia and weight loss No No No No No No Yes No No
178 4 Several years history of hypogonadism (he had small penis and no pubic hair); history of polyuria and polydipsia; 4 months history of headaches, visual disturbances. Yes Yes No No No No Yes No No
179 right flank pain, acute renal failure, vomiting No Yes No No No No No No No
180 polyuria, polydipsia, fatigue, headaches, weight loss Yes No Yes No No No Yes No No
181 Headache Yes No No No No No No No No
182 polyuria, polydipsia No No No No No No Yes No No
183 meningitis (headache, fever, leukocytosis in the CSF) Yes No No No No No No No No
184 amenorrhea No No No No No No No Yes No
185 Headaches, nausea, vomiting. Yes No Yes No No No No No No
186 Headache Yes No No No No No No No No
187 Visual field defects, headaches. Yes Yes No No No No No No No
188 headaches, nausea and vomiting Yes No Yes No No No No No No
189 Headaches, visual field defects Yes Yes No No No No No No No
190 polyuria No No No No No No Yes No No
191 headaches, fatigues, amenorrhea Yes No Yes No No No No Yes No
192 polyuria, polydipsia No No No No No No Yes No No
193 36 3 years history of polydipsia No No No No No No Yes No No
194 9 9 months history of headaches. Yes No No No No No No No No
195 8 8 months history of fatigue, polyuria and polydipsia No No Yes No No No Yes No No
196 2 2 months history of headache, polyuria and polydipsia, amenorrhea Yes No No No No No Yes Yes No
197 several years history of visual disturbances (ophthalmoplegia) No Yes No No No No No No No
198 36 During the 1st pregnancy delivery was induced at weeks 32 by cesarean section for fetal distress. Symptoms (headache) improved spontaneously after delivery. At 28 weeks of the 2nd pregnancy, headache and fever again. Delivery performed by cesarean section at week 37. After delivery, symptoms continued then joint pain and cold intolerance appeared. Sheehan's syndrome was suspected Yes No Yes Yes No No No No No
199 24 3 years history of polyuria and polydipsia No No No No No No Yes No No
200 Known Graves' disease. Two years later he developed secondary hypothyroidism, and thus pituitary function was investigated. No No No Yes No No No No No
201 Visual field defects No Yes No No No No No No No
202 Fatigue, visual field defects No Yes Yes No No No No No No
203 Headaches and visual field defects Yes Yes No No No No No No No
204 Visual field defects. Then failure to lactate No Yes No No Yes No No No No
205 Fatigue, headaches, polyuria, polydipsia, cold intolerance, dry skin Yes No Yes Yes No No Yes No No
206 decreased libido No No No No No Yes No No No
207 Diplopia, headaches, vomiting, polyuria, polydipsia Yes Yes Yes No No No Yes No No
208 polyuria, polydipsia, short stature No No No No No No Yes No No
209 polyuria, polydipsia, short stature No No No No No No Yes No No
210 Amenorrhea No No No No No No No Yes No
211 Death from multiple trauma No No No No No No No No No
212 polyuria, polydipsia No No No No No No Yes No No
213 Fatigue, weight loss, polydipsia, beginning chiasm syndrome No No Yes No No No Yes No No
214 Headaches, visual field defects Yes Yes No No No No No No No
215 Headaches, fatigue Yes No Yes No No No No No No
216 2 2 months history of polyuria, polydipsia and fatigue No No No No No No Yes No No
217 7 7 months history of anorexia, weight loss, headaches, amenorrhea. More recently she noticed cold intolerance, dry skin, fatigue, polyuria and polydipsia. Then acute onset of aseptic meningitis: headaches, vomiting and progressive lethargy. CSF contained 1000 cells/cc (50% poly, 30% lymphocytes, 4% eosinophils, 17% non white cells). All cultures were negative. Yes No Yes Yes No No Yes Yes No
218 9 Recent history of anorexia, weight loss, fatigue, severe hypoglycemia and reduced consciousness. 9 months history of Hashimoto's thyroiditis. 4 years history of sarcoidosis. Patient had no signs of posterior pituitary insufficiency or systemic sarcoid activity. No No Yes No No No No No No
219 60 5 years history of weakness, palpitation, cold sweating No No Yes No No No No No No
220 60 5 years history of polyuria and polydipsia No No No No No No Yes No No
221 30 2.5 years history of polyuria and polydipsia No No No No No No Yes No No
222 24 2 years history of polyuria and polydipsia No No No No No No Yes No No
223 polyuria and polydipsia No No No No No No Yes No No
224 collapse due to pituitary apoplexy No No Yes No No No No No No
225 secondary amenorrhea No No No No No No No Yes No
226 18 1.5 years history of panhypopituitarism No No Yes Yes No Yes No No No
227 Headache, visual field defects Yes Yes No No No No No No No
228 6 6 months history of visual disturbances No Yes No No No No No No No
229 meningoencephalitis Yes No No No No No No No No
230 12 12 months history of polyuria and polydipsia, decreased libido, impotence, fever No No No No No Yes Yes No No
231 1 1 month history of thirst, polyuria and polydipsia. 2 days history of fever. She was hospitalized for suspected diabetes insipidus. No No No No No No Yes No No
232 4 4 months history of headache, 2 months history of polydipsia, polyuria, recent history of visual field defects No Yes No No No No Yes No No
233 2 2 months history of intermittent headaches. Normal menses. Normal eye and neurological exam. Yes No No No No No No No No
234 2 2-month history of polyuria (9 liters per day) and polydipsia. Occasional headache. Water deprivation test, followed by pitressin injection, confirm central diabetes insipidus. Yes No No No No No Yes No No
235 72 6 years history of slowly progressive hypopituitarism No No Yes No No No No No No
236 4 4 months history of headaches and chiasm compression Yes No No No No No No No No
237 6 6 months history of amenorrhea. No No No No No No No Yes No
238 1 1 month history of suddenly appearing polyuria and polydipsia No No No No No No Yes No No
239 6 A 6 months history of progressive hypopituitarism No No Yes Yes No No No No No
240 18 1.5 years history of polyuria and polydipsia appeared suddenly. No No No No No No Yes No No
241 2 2 months history of polydipsia and polyuria, suddenly appeared. No No No No No No Yes No No
242 2 2 months history of polyuria and polydipsia, suddenly appearing. No No No No No No Yes No No
243 18 1.5 years history of progressively decreasing performance. No No Yes No No No No No No
244 Progressive weakness, malaise, decreased axillary and pubic hair, diminished appetite, weight loss. Patient was not able to lactate; however, 6 months later she developed galactorrhea. No No Yes No Yes No No Yes No
245 6 6 months history of weight loss, weakness, lethargy, reduced libido and cold intolerance. No No Yes Yes No Yes No No No
246 Secondary amenorrhea. An hypophyseal tumor was suspected. There are no endocrinological data. Patient underwent transphenoidal surgery. After surgery she received replacement with estrogen/progesterone, prednisolone and somatotropin. 18 months after surgery she developed pain and swelling of the left lachrymal gland No No No No No No No Yes No
247 1 Galactorrhea followed 2 weeks later by polyuria and polydipsia No No No No No No Yes Yes No
248 sudden onset of polydipsia, polyuria and headaches. Yes No No No No No Yes No No
249 5 5 months history of polyuria and polydipsia No No No No No No Yes No No
250 2 2 months history of headaches Yes No No No No No No No No
251 1 1 month history of headaches, fever and double vision; 2 weeks history of fatigue, nausea and vomiting. Yes Yes Yes No No No No No No
252 36 3 years history of dry mouth and eyes, then diagnosed as SjÜgren's syndrome. 4 months history of headaches, dizziness and general malaise. Then during hospitalization polyuria and polydipsia. Yes No No No No No Yes No No
253 visual field defects. Delivery was done in the 38th week of pregnancy by cesarean section. Visual disturbances increased. No Yes No No No No No No No
254 24 2 years history of polyuria, polydipsia, loss of appetite and secondary enuresis. She was diagnosed with central diabetes insipidus and began desmopressin therapy. No No No No No No Yes No No
255 polydipsia and polyuria. She delivered at term, was able to breast-feed but noted an impaired lactation until the 3rd month postpartum when she came to the medical attention. No No No No Yes No Yes No No
256 24 1 year history of headaches that began at the time of menopause (49 years) and secondary hypothyroidism (treated with thyroxine). She was also receiving methylprednisolone for a diagnosis of erythema nodosum, diagnosed 4 years ago Yes No No Yes No No No No No
257 0 5 days of headaches, nausea and vomiting Yes No Yes No No No No No No
258 Recent onset of headaches and excessive thirst. She then developed polydipsia and polyuria Yes No No No No No Yes No No
259 2 2 months history of polyuria, polydipsia and fatigue No No No No No No Yes No No
260 6 6 months history of headache and galactorrhea Yes No No No No No No Yes No
261 3 3 months history of fatigue, headache, diplopia and loss of libido. He had a 15 years history of pan-hypopituitarism treated with thyroxine, prednisolone and testosterone, which he discontinued 3 months before admission. Yes Yes Yes Yes No Yes No No No
262 2 2 months history of polydipsia and polyuria. No No No No No No Yes No No
263 0 2 weeks history of polyuria, polydipsia and insomnia, which developed gradually No No No No No No Yes No No
264 24 2 years history of polydipsia and polyuria No No No No No No Yes No No
265 polydipsia began at age 9. At this time MRI was normal, endocrine work-up confirmed diabetes insipidus and suggested a growth hormone deficiency. At age 12, however, repeat MRI was positive No No No No No No Yes No No
266 History of excess thirst. He would drink anything, including warm water. There was a 6-lb weight loss in recent months. Test of anterior pituitary function were normal. The child was diagnosed as diabetes insipidus and MRI performed. No No No No No No Yes No No
267 3 3 months history of facial malar rash, fever, generalized myalgia, hair loss and arthralgia, then headaches and nausea Yes No Yes No No No No No No
268 8 8 months history of hepatitis, then diagnosed as autoimmune, and 4 months history of Graves' disease. 2 weeks history of tempo-spatial disorientation and asterixis No No No No No No No No Yes
269 72 6 years history of fatigue. 6 months before admission a collapse with fever. Thyroid hormones were low with low TSH. MRI showed a pituitary mass, 11 mm high, extended into the suprasellar cistern. She started thyroxine and prednisone with some improvements but still feeling tired. 1 month before admission, visual field defects. No Yes Yes Yes No No No No No
270 Headaches, then visual field defects. After the 32nd week visual acuity deteriorated, thus surgery was performed. Yes Yes No No No No No No No
271 6 6 months history of headaches, polyuria, polydipsia and nicturia. Yes No No No No No Yes No No
272 6 6 months history of polydipsia and polydipsia, 3 months history of bilateral swelling of submandibular salivary glands No No No No No No Yes No No
273 xerostomia and polyuria (6 L per day) No No No No No No Yes No No
274 Patient had ALL at age 13, treated, no recurrence. At age 20 she developed polyuria, polydipsia and amenorrhea, fatigue, dry skin, anemic, easiness of bleeding. No visual problems. No No No No No No Yes No No
275 Polydipsia, polyuria, unnaturally strong thirst. Then headaches and hypopituitarism (not otherwise studied or specified) Yes No No No No No Yes No No
276 Headaches and visual field defects Yes Yes No No No No No No No
277 18 Diplopia with bilateral 6t and 7th nerve palsies. Then 18 months history of panhypopituitarism and 13 months history of deteriorating visual acuity. No Yes Yes Yes No Yes No No No
278 Headaches and amenorrhea. Then panhypopituitarism. Yes No No No No No No Yes No
279 Visual field defects, galactorrhea, headaches Yes Yes No No No No No Yes No
280 12 12 months history of headaches, anorexia and fatigue. Yes No Yes Yes No No No No No
281 5 5 months history of polyuria, polydipsia, galactorrhea and headache. Yes No No No No No Yes Yes No
282 3 3 months history of polyuria and polydipsia No No No No No No Yes No No
283 headaches and diplopia that spontaneously improved. Then, generalized fatigue and anorexia. Yes Yes Yes No No No No No No
284 3 3 months history of headaches, polyuria and polydipsia. Endocrine tests diagnosed diabetes insipidus and desmopressin was started with good control of polyuria and polydipsia. Headaches persisted. Yes No No No No No Yes No No
285 headaches, visual field defects and oligomenorrhea Yes Yes No No No No No Yes No
286 visual field defects. No Yes No No No No No No No
287 Fever, arthromyalgia and pharyngeal pain, diagnosed as Still's disease. 1 year later lymphocytic meningitis. 2.5 years later headaches, polyuria/polydipsia and galactorrhea/amenorrhea Yes No No No No No Yes Yes No
288 3 3 months history of fatigue and weight loss. He felt at home and was brought in by his family. In the hospital increased calcemia was found, so the patient was rehydrated. He then became hypotensive, confused, arrhythmic and died No No Yes No No No No No No
289 0 1 week history of bilateral visual deterioration. Then she began to complain of headaches. She was not able to begin lactating. Yes Yes No No Yes No No No No
290 0 5 days history of increasing fatigue and energy loss. She noticed a puffy face and felt nauseous. No No Yes Yes No No No No No
291 4 4 months history of amenorrhea and visual field defects; 2 months history of polyuria, polydipsia, decreased libido and constipation No Yes No Yes No Yes Yes Yes No
292 10 galactorrhea. She had stopped breast-feeding 6 months after her 1st delivery and started oral contraceptives. 10 months after delivery she developed galactorrhea with increased prolactin. Galactorrhea resolved with bromocriptine but recurred when bromocriptine was stopped No No No No No No No Yes No
293 Nausea, vomiting and constipation. After her second delivery (19 years before presentation) lactation was impaired. In the early thirties she gradually became oligomenorrhoic, and noticed loss of pubic and axillary hair. She had several episodes of loss of consciousness associated with hypoglycemia. No No Yes Yes Yes No No Yes No
294 0 2 weeks history of fatigue, anorexia, cold intolerance, decreased libido and impotence No No Yes Yes No Yes No No No
295 3 3 months history of polyuria and polydipsia; 1 week history of decreased visual acuity No Yes No No No No Yes No No
296 36 3 years history of panhypopituitarism No No Yes Yes No Yes No No No
297 Yes Yes No No No No No No No
298 No No No No No No Yes No No
299 No No Yes No No No No No No
300 polyuria and polydipsia No No No No No No Yes No No
301 polyuria and polydipsia No No No No No No Yes No No
302 polyuria and polydipsia No No No No No No Yes No No
303 48 4 years history of polyuria and polydipsia (with preference for ice-cold water), suddenly appeared. On admission to the hospital, water deprivation and desmopressin test revealed central diabetes insipidus No No No No No No Yes No No
304 1 One and a half month history of polyuria and polydipsia (15 L per day). Water deprivation and pitressin test revealed central diabetes insipidus No No No No No No Yes No No
305 36 Three years history of weight increase, gynecomastia and polyuria. Erection occurred but without ejaculation. No axillary, pubic or facial hair growth had developed. No No No No No Yes Yes No No
306 5 5 months after an uneventful pregnancy and delivery the patient was admitted to the hospital intensive care unit because of severe hypotension, lethargy and tachycardia. The patient had been unable to lactate and menses had not returned after delivery No No Yes Yes Yes No No No No
307 Headaches, vomiting, fever Yes No Yes No No No No No No
308 2 2 months history of headaches and galactorrhea; 2 days history of diplopia. Yes Yes No No No No No Yes No
309 Headaches, visual field defects Yes Yes No No No No No No No
310 8 8 months history of headaches Yes No No No No No No No No
311 Headaches, then visual field defects. Yes Yes No No No No No No No
312 Headaches, visual field defects Yes Yes No No No No No No No
313 No No No No No No No No No
314 Amenorrhea and galactorrhea No No No No No No No Yes No
315 No No No No No No No No No
316 No No No No No No No No No
317 No No No No No No No No No
318 No No No No No No No No No
319 Visual field defects No Yes No No No No No No No
320 Visual field defects No Yes No No No No No No No
321 Headaches Yes No No No No No No No No
322 Headaches and polyuria and polydipsia Yes No No No No No Yes No No
323 Polyuria and polydipsia No No No No No No Yes No No
324 No No No No No No No No No
325 No No No No No No No No No
326 Polyuria and polydipsia No No No No No No Yes No No
327 Polyuria and polydipsia No No No No No No Yes No No
328 No No No No No No No No No
329 Headaches, visual field defects Yes Yes No No No No No No No
330 No No No No No No No No No
331 Polyuria and polydipsia, galactorrhea and amenorrhea No No No No No No Yes Yes No
332 Dizziness No No Yes No No No No No No
333 Polyuria and polydipsia, galactorrhea No No No No No No Yes Yes No
334 4 4 year history of amenorrhea, 4 months history of polyuria and polydipsia and 2 months history of vision loss in the left eye. No Yes No No No No Yes Yes No
335 visual field defects No Yes No No No No No No No
336 0 2 weeks history of headaches, suddenly appeared Yes No No No No No No No No
337 24 3 years and 2 years before referral, she had two episodes of fever, headaches, photophobia, neck stiffness, abnormal visual field, and lymphocytosis in the CSF diagnosed as aseptic meningitis. She received antibiotics and steroids and improved in a week. She then developed cold intolerance, fatigue and amenorrhea. Yes Yes Yes Yes No No No Yes No
338 headache, nausea and bilious vomit. Then, 48 hours later, lacrimation, photophobia, diplopia and ptosis of the right eye. Yes No No No No No No No No
339 Headaches. They became more persistent and severe in the 33rd week of pregnancy, and were accompanied by vomiting. She delivered at term by cesarean section. Yes No No No No No No No No
340 12 12 months history of fatigue, 9 months history of anorexia, weight loss, decreased libido, impotence No No Yes Yes No Yes No No No
341 headaches, visual disturbances, fatigue, joint pain. She began hydrocortisone and thyroxine and delivered by caesarian section a healthy baby. She was able to breastfeed only for 10 days. 1 month after delivery she complained of dizziness and generalized weakness. Yes Yes Yes No No No No No No
342 2 2 months history of poor appetite and cold intolerance. Then 2 episodes of loss of consciousness. She was admitted to the hospital where they found hypotension and persistent hypoglycemia No No Yes Yes No No No No No
343 Fatigue and finger tremors No No Yes No No No No No No
344 48 4 years before admission the patient was diagnosed with diabetes insipidus (treated with desmopressin), hypogonadotropic hypogonadism and myositis of the left extraocular muscle. Anti-ds DNA antibodies were positive. Orbital pain and swelling were relieved by corticosteroids. 7 months before admission he began weekly im injections of hCG because he desired a child (testosterone was not given because he was potent). 2 months before admission he noted a butterfly rash on his face and general malaise, then high fever and headaches. Yes No No No No No Yes No No
345 36 3 years history of intermittent headaches and ocular pain of the right eye. She assumed pain relief medication. Mild hypertension in the past 10 years, untreated. No family history. Menarche was at 15 and menopause at 52. PE showed no exophthalmia or ophthalmoplegia. Negative neurological exam. Yes Yes No No No No No No No
346 2 2 months history of nausea and headaches. The first pregnancy and post-partum were fine. No family history. PE showed acromegalic features of the face. Neurological and fundoscopic exams were normal. Yes No No No No No No No No
347 12 12 months history of weakness, constipation, decreased libido, impotence, weight loss. 8-month history of headache and dizziness. 1-month history of visual disturbances, nausea and vomiting. Yes Yes No Yes No Yes No No No
348 1 1-month history of headache, vomiting, and discomfort in his eye region. 2-weeks history of appetite loss and general fatigue. Yes Yes No No No No No No No
349 0 2-weeks history of worsening vision in both eyes, headache, nausea, vomiting and tiredness. Yes Yes No No No No No No No
350 2 2-month history of headache and periorbital pain. 3-weeks history of fatigue, weight gain, polyuria, polydipsia and diplopia. Yes Yes No No No No Yes No No
351 Sudden "fog" in the left eye, associated with headache on awakening. Almost presenting as pituitary apoplexy. Yes Yes No No No No No No No
352 3 The patient presented 1 month post-partum for progressive visual failure which began in the third trimester No Yes No No No No No No No
353 0 2 weeks history of nausea, vomiting, anorexia and lethargy No No Yes No No No No No No
354 24 2 year history of decreased libido and bitemporal headache Yes Yes No No No Yes No No No
355 2 2 months history of headache, polydipsia and polyuria Yes No No No No No Yes No No
356 2 2 months history of headache and decreased visual acuity Yes Yes No No No No No No No
357 sudden appearance of polyuria (with weight loss) 6 liters a day. No No No No No No Yes No No
358 sudden onset of polyuria (5 liters a day). Vision, neurological and endocrinological tests were normal. No No No No No No Yes No No
359 12 polydipsia and polyuria, followed by left hemiparesis, dysarthria and restlessness lasting 1 year. No No No No No No Yes No No
360 1 One-month history of anorexia, nausea, vomiting, cold intolerance, blurring of vision, and disagreeable odors. Three months history of secondary amenorrhea and galactorrhea. No Yes Yes Yes No No No Yes No
361 102 8.5 years before admission the patient developed secondary hypothyroidism, which was misdiagnosed as primary hypothyroidism and treated with T4 without further investigations. 4.5 years before admission, she developed vomiting and generalized weakness. She was diagnosed with hypopituitarism and treated with hydrocortisone. A CT scan at that time showed a normal sized pituitary with a 6x4 mm hypodense area. She presented with 2-month history of progressive bilateral decrease in vision, while under T4 and steroid replacement. No No No Yes No No No No No
362 7 Patient presented about 7 months after her third delivery with bilateral proptosis, which MRI showed to be caused by enlarged lachrymal glands. Endocrine tests were all normal except for a suppressed TSH and slightly increased TSH receptor antibodies. No No No No No No No No Yes
363 36 3 years history of headache, diplopia, decreased libido, weight gain, lethargy. Patient was on cortisol, thyroxine and testosterone when seen. Yes Yes Yes Yes No Yes No No No
364 36 3-years history of headache, amenorrhea, weight gain, meningism. No visual impairment. Yes No Yes Yes No Yes No Yes No
365 1 One-month history of headache, decreased libido, weight loss. A prolactinoma was resected 19 years before presentation. No visual impairment. Yes No Yes No No Yes No Yes No
366 3 3-months history of headache, decreased libido, weight gain, lethargy. No visual impairment. She was receiving cortisol replacement when seen. Yes No Yes Yes No No No No No
367 1 1-month history of headache, weight loss, galactorrhea. No visual impairment. Yes No Yes No No No No No No
368 12 1-year history of headache, amenorrhea, weight gain, lethargy, bitemporal hemianopsia Yes Yes Yes Yes No Yes No No No
369 4 4-months history of headache, decreased libido, amenorrhea, weight gain, lethargy. No visual impairment. The patient was taking thyroxine for hypothyroidism of unknown nature. Yes No Yes No No Yes No No No
370 60 5-years history of headache, decreased libido, weight gain, lethargy. No visual disturbances. Yes No No No No Yes No Yes No
371 1 1-month history of decreased libido, amenorrhea, weight gain, polyuria, lethargy, bitemporal hemianopsia No Yes Yes Yes Yes Yes Yes No No
372 12 1-year history of polyuria and bitemporal hemianopsia. When the patient was seen is was already taking corticosteroids, thyroxine and testosterone and he had a history of transphenoidal surgery for lymphocytic hypophysitis at another center. No Yes Yes Yes No Yes Yes No No
373 5 decreased libido, weight loss, polyuria, lethargy. No visual disturbances. No No No No No Yes Yes No No
374 36 lethargy. He was already taking corticosteroid, thyroxine and testosterone when seen. No No Yes Yes No Yes No No No
375 4 headache, lethargy. Yes No No Yes No No No No No
376 Patient was admitted for controls of his type 1 diabetes mellitus with positive GAD antibodies and islet cell antibodies. Lab tests revealed increased creatine kinase and cholesterol, associated with decreased FT4 and low TSH. Endocrine stimulation tests revealed absent response of TSH, PRL and GH. ACTH and gonadotropin were normal No No No Yes No No No No No
377 long-term history (25 years) of failed sexual development No No No No No Yes No No No
378 2 2 months history of visual field defects No Yes No No No No No No No
379 9 9 months history of fatigue, 6 months history of impotence, 2 months history of visual field defects No Yes No No No Yes No No No
380 12 Acromegalic appearance. One year history of loss of libido, impotence No No Yes No No Yes No No No
381 9 9 months history of headaches; 2 months history of amenorrhea and galactorrhea Yes No No No No No No Yes No
382 2 2 months history of suddenly appeared polydipsia and polyuria No No No No No No Yes No No
383 12 12 months history of polyuria and polydipsia and 2 months history of gradually decreasing visual acuity. No Yes No No No No Yes No No
384 This girl had a history of polyuria and polydipsia diagnosed at the age of 8 as central diabetes insipidus. At age 10 she developed gonadotropins and GH deficiency. At age 12 she developed hypothyroidism. No No No No No No Yes No No
385 48 4 years history of polyuria and polydipsia, diagnosed as central, idiopathic diabetes insipidus, without defects of anterior pituitary function. The boy then developed a growth defect that prompted a repeat of pituitary function tests that show panhypopituitarism No No No Yes No Yes Yes No No
386 Patient presented as meningitis. MRI showed thickening (4 mm) of the pituitary stalk. Endocrine tests revealed a deficit of the anterior hypophysis. Patient underwent transphenoidal surgery but the lesion was inaccessible. 6 months later patient developed hemianopsia bitemporalis Yes Yes No No No No No No No
387 Fatigue, fronto-orbital headache, abrupt appearance of diplopia, plus ptosis and mydriasis in the right eye. No clinical signs of adenohypophyseal insufficiency or diabetes insipidus. Yes Yes No No No No No No No

 


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