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Pancreas Cancer
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FAQs
1 The Pancreas
2 Pancreatic Cancer
3 Causes of PC
4 Heredity
5 Risk Factors
6 Diagnosis
7 Metastasis
8 Staging
9 Questions to ask
10 Surgical Treatment
11 Medical Treatment
12 Vaccine
13 Symptoms & Side Effects
14 Screening
15 Pain Management
16 Diet & Exercise
17 Final Stages & Hospice


Glossary of Terms
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Abdomen The portion of the body between the diaphragm and the pelvis.
Abscess A pus-filled cavity.

Adenocarcinoma

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The form of cancer that most people are talking about when they refer to "cancer of the pancreas." These tumors account for 75% of all pancreas cancers.

Microscopically, adenocarcinomas form glands. These tumors can grow large enough to invade nerves which can cause back pain. They also frequently spread (metastasize) to the liver or lymph nodes. If this happens the tumor may be considered unresectable.
Adenoma A benign (non-cancerous) tumor made up of cells that form glands (collections of cells surrounding an empty space).
Adjuvant chemotherapy Chemotherapy given to patients after their cancers have been surgically removed. It is a secondary treatment given to supplement surgical treatment. (see Neoadjuvant chemotherapy)
Ampulla of Vater             This widening of the pancreatic duct is an landmark for physicians. It is where the bile duct and pancreatic duct join before draining into the duodenum (small intestine). Tumors in the head of the pancreas may squeeze this duct partially or completely closed. This can lead to problems with digestion and jaundice.
Anastamosis A surgical joining of two hollow structures. It is similar to attaching two ends of a garden hose. For example, a gastrojejunostomy is a surgical procedure that connects the stomach and the jejunum (small intestine.)
Anemia A condition characterized by a deficiency in red blood cells. This can lead to fatigue among other symptoms.
Anorexia A condition marked by a diminished apetite and aversion to food. Often results in physical signs of wasting.
Angiography A radiographic technique used to visualize blood vessels. A contrast medium (a dye) is usually injected into the vessels to make them appear white on the x-rays.
Aorta The large artery that carries oxygen-rich blood from the heart. It descends into the abdomen where it gives off many branches to supply the organs. The superior mesenteric artery is a major branch of the aorta that is a common site of pancreatic cancer metastases.
Ascites The collection of excess amounts of fluid in the abdominal cavity (belly). It often is a sign that the cancer has spread to either the liver or the portal vein that goes to the liver. If normal liver function is affected, a complex set of biochemical checks and balances is disrupted and abnormal amounts of fluid are retained.
Benign tumors Tumors which are non-cancerous. These generally grow slowly and do not invade adjacent organs or spread (metastasize) beyond the pancreas.
Bile A green fluid produced by the liver that helps digest fats. It is transported from the liver to the duodenum by the bile duct. When the flow of bile is blocked, patients may become jaundiced (yellow skinned).
Bile duct A duct that carries bile from the liver to the intestine. This term may refer to the hepatic, cystic or common bile duct.
Biopsy The removal and microscopic examination of a tissue sample.
Blastoma A primitive tumor that develops in childhood. (pancreatoblastoma)
Body of the pancreas The middle part of gland between the neck and the tail. The superior mesenteric blood vessels run behind this part of the gland.
CA19-9 A blood marker for pancreas cancer. It is not a good screening test for diagnosing possible pancreas cancers. However, it can be useful in following the progress of patients known to have a cancer by measuring how their cancer is responding to treatment.
Cachexia A dramatic weight loss and general wasting that occurs during chronic disease.
Cancer A malignant tumor. It has the potential of invading into the adjacent tissues, spreading to other organs and may eventually lead to the patient's death.
Carcinogen A cancer-causing agent.
Carcinoma A malignant (cancerous) new growth. These tumors infiltrate into surrounding tissues and, if untreated, will spread to other organs, and may eventually lead to the patient's death.
Catheter A small, flexible tube inserted into the body to inject or suck out fluids.
Chemotherapy The treatment of a cancer by chemicals. For pancreatic cancer these include: Gemzar (Gemcitabine), 5-flurouracil, leukovorin, mitomicin C, and others.
Computed Tomography (CT) Scan A series of x-ray pictures taken by a machine that encircles the body like a giant tube. Computers are then used to generate cross-sectional images of the inside of the body.
Contrast agent (or medium) A dye, taken by mouth or injected, that is sometimes used during x-ray examinations to highlight areas that otherwise might not be seen.
Cyst A fluid filled sac. Some tumors of the pancreas, including the serous cystadenoma and mucinous cystadenocarcinomas are cystic. These have a distinct appearance in CT scans. They are important to recognize because the treatment of cystic tumors can differ from that for solid tumors.
Reference: The Johns Hopkins Family Health Book; Michael J. Klag Editor, Harper Collins Pub., 1999.

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This site is supported by generous educational grants from the Vesalius Trust

Disclaimer: No two patients with pancreas cancer are identical. The appropriate treatment of individual patients with pancreatic cancer varies greatly depending on the patient's medical and surgical history. The information expressed in this Web page is not medical advice. It is meant only to educate health care professionals and patients about the current status of treatment and research in pancreas cancer at Hopkins. Before making any medical decisions, patients with pancreatic cancer are advised to consult with their personal physicians.