Selected References by Hopkins' Pancreas Cancer Researchers
Matsen SL, Yeo CJ, Hruban RH, Choti MA. Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review. J Gastrointest Surg. 2005 Feb;9(2):270-9. abstract
Sato N, Parker AR, Fukushima N, Miyagi Y, Iacobuzio-Donahue CA, Eshleman JR, Goggins M. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene. 2005 Jan 27;24(5):850-8. abstract
Sato N, Matsubayashi H, Fukushima N, Goggins M. The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic Cancer. Cancer Biol Ther. 2005 Jan 15;4(1) abstract
Hustinx SR, Hruban RH, Leoni LM, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Brown PN, Argani P, Asfaq R, Fukushima N, Goggins M, Kern SE, Maitra A. Homozygous Deletion of the MTAP Gene In Invasive Adenocarcinoma of the Pancreas and in Periampullary Cancer: A Potential New Target for Therapy. Cancer Biol Ther. 2005 Jan 15;4(1). abstract
Matsubayashi H, Sato N, Brune K, Blackford AL, Hruban RH, Canto M, Yeo CJ, Goggins M. Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):573-83. abstract
Cao D, Maitra A, Saavedra JA, Klimstra DS, Adsay NV, Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol. 2005 Jan 14; abstract
Henke RT, Maitra A, Paik S, Wellstein A. Gene expression analysis in sections and tissue microarrays of archival tissues by mRNA in situ hybridization. Histol Histopathol. 2005 Jan;20(1):225-37. abstract
Rosty C, Goggins M. Identification of differentially expressed proteins in pancreatic cancer using a global proteomic approach. Methods Mol Med. 2004;103:189-98. abstract
Curtis CD, Goggins M. DNA methylation analysis in human cancer. Methods Mol Med. 2004;103:123-36. abstract
Hruban RH, Wilentz RE, Maitra A. Identification and analysis of precursors to invasive pancreatic cancer. Methods Mol Med. 2004;103:1-14. abstract
Walter K, Eshleman J, Goggins M. Xenografting and harvesting human ductal pancreatic adenocarcinomas for DNA analysis. Methods Mol Med. 2004;103:103-12. abstract
Xin W, Yun KJ, Ricci F, Zahurak M, Qiu W, Su GH, Yeo CJ, Hruban RH, Kern SE, Iacobuzio-Donahue CA. MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res. 2004 Dec 15;10(24):8516-20. abstract
Amador ML, Oppenheimer D, Perea S, Maitra A, Cusati G, Iacobuzio-Donahue C, Baker SD, Ashfaq R, Takimoto C, Forastiere A, Hidalgo M. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. Cancer Res. 2004 Dec 15;64(24):9139-43. abstract
Rogers CD, Couch FJ, Brune K, Martin ST, Philips J, Murphy KM, Petersen G, Yeo CJ, Hruban RH, Goggins M. Genetics of the FANCA gene in familial pancreatic cancer. J Med Genet. 2004 Dec;41(12):e126. No abstract available.
Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004 Dec 2;23(56):9042-51. abstract
Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Kern SE, Goggins M, Mollenhauer J, Pandey A, Hruban RH. Differentially Expressed Genes in Pancreatic Ductal Adenocarcinomas Identified Through Serial Analysis of Gene Expression. Cancer Biol Ther. 2004 Dec 14;3(12). abstract
Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res. 2004 Sep-Oct;3(5):1042-55. abstract
Cao D, Hustinx SR, Sui G, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CJ, Kern SE, Goggins M, Pandey A, Hruban RH. Identification of Novel Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas through a Bioinformatics Analysis of Expressed Sequence Tags. Cancer Biol Ther. 2004 Nov 12;3(11). abstract
Kawamoto S, Siegelman SS, Hruban RH, Fishman EK. Lymphoplasmacytic sclerosing pancreatitis with obstructive jaundice: CT and pathology features. AJR Am J Roentgenol. 2004 Oct;183(4):915-21. abstract
Brody JR, Calhoun ES, Gallmeier E, Creavalle TD, Kern SE. Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media. Biotechniques. 2004 Oct;37(4):598, 600, 602. abstract
Matsubayashi H, Fujiwara S, Kobayashi Y, Iiri T, Mitra A, Goggins M, Hruban RH, Moriyasu F. A small cell carcinoma of the pancreas with a high level of serum ProGRP. J Clin Gastroenterol. 2004 Oct;38(9):834-5. No abstract available.
Sato N, Maehara N, Goggins M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 2004 Oct 1;64(19):6950-6. abstract
Brody JR, Kern SE. History and principles of conductive media for standard DNA electrophoresis. Anal Biochem. 2004 Oct 1;333(1):1-13. abstract
Koopmann J, Thuluvath PJ, Zahurak ML, Kristiansen TZ, Pandey A, Schulick R, Argani P, Hidalgo M, Iacobelli S, Goggins M, Maitra A. Mac-2-binding protein is a diagnostic marker for biliary tract carcinoma. Cancer. 2004 Oct 1;101(7):1609-15. abstract
Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ, Maitra A. Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6152-8. abstract
Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A, Riegel AT. Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6134-42. abstract
Thomas AM, Santarsiero LM, Lutz ER, Armstrong TD, Chen YC, Huang LQ, Laheru DA, Goggins M, Hruban RH, Jaffee EM. Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med. 2004 Aug 2;200(3):297-306. abstract
van der Heijden MS, Brody JR, Gallmeier E, Cunningham SC, Dezentje DA, Shen D, Hruban RH, Kern SE. Functional defects in the fanconi anemia pathway in pancreatic cancer cells. Am J Pathol. 2004 Aug;165(2):651-7. abstract
Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, Biankin SA, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, Shimizu M, Yonezawa S. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004 Aug;28(8):977-87. abstract
Canto MI, Goggins M, Yeo CJ, Griffin C, Axilbund JE, Brune K, Ali SZ, Jagannath S, Petersen GM, Fishman EK, Piantadosi S, Giardiello FM, Hruban RH. Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clin Gastroenterol Hepatol. 2004 Jul;2(7):606-21. abstract
Adsay NV, Merati K, Basturk O, Iacobuzio-Donahue C, Levi E, Cheng JD, Sarkar FH, Hruban RH, Klimstra DS. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004 Jul;28(7):839-48. abstract
Van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M. Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther. 2004 Jul;3(7):651-6. abstract
Van Der Heijden MS, Brody JR, Kern SE. Functional screen of the fanconi anemia pathway in cancer cells by fancd2 immunoblot. Cancer Biol Ther. 2004 Jun;3(6):534-7. abstract
Koopmann J, Goggins M, Hruban RH. Case 7-2004: hereditary melanoma and pancreatic cancer. N Engl J Med. 2004 Jun 17;350(25):2623-4; author reply 2623-4. No abstract available.
Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg. 2004 Jun;239(6):788-97; discussion 797-9. abstract
Maitra A, Cohen Y, Gillespie SE, Mambo E, Fukushima N, Hoque MO, Shah N, Goggins M, Califano J, Sidransky D, Chakravarti A. The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res. 2004 May;14(5):812-9. abstract
Meeker AK, Hicks JL, Iacobuzio-Donahue CA, Montgomery EA, Westra WH, Chan TY, Ronnett BM, De Marzo AM. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004 May 15;10(10):3317-26. abstract
Takaori K, Hruban RH, Maitra A, Tanigawa N. Pancreatic intraepithelial neoplasia.
Pancreas. 2004 Apr;28(3):257-62. abstract
Koopmann J, Buckhaults P, Brown DA, Zahurak ML, Sato N, Fukushima N, Sokoll LJ, Chan DW, Yeo CJ, Hruban RH, Breit SN, Kinzler KW, Vogelstein B, Goggins M. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res. 2004 Apr 1;10(7):2386-92. abstract
Klein AP, Brune KA, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, Griffin C, Cameron JL, Yeo CJ, Kern S, Hruban RH. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004 Apr 1;64(7):2634-8. abstract
House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD, Hruban RH, Horton KM, Fishman EK, Lillemoe KD. Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg. 2004 Mar-Apr;8(3):280-8. abstract
Choti MA. Adjuvant therapy for pancreatic cancer--the debate continues. N Engl J Med. 2004 Mar 18;350(12):1249-51. Full Text
Swierczynski SL, Maitra A, Abraham SC, Iacobuzio-Donahue CA, Ashfaq R, Cameron JL, Schulick RD, Yeo CJ, Rahman A, Hinkle DA, Hruban RH, Argani P. Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Hum Pathol. 2004 Mar;35(3):357-66. abstract
Iacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, Kern SE. Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res. 2004 Mar 1;10(5):1597-604. abstract
Koopmann J, Fedarko NS, Jain A, Maitra A, Iacobuzio-Donahue C, Rahman A, Hruban RH, Yeo CJ, Goggins M. Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):487-91. abstract
Sato N, Fukushima N, Maitra A, Iacobuzio-Donahue CA, van Heek NT, Cameron JL, Yeo CJ, Hruban RH, Goggins M. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol. 2004 Mar;164(3):903-14. abstract
Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, Troup WJ, Romm JM, Doheny K, Pugh E, Yeo CJ, Goggins MG, Hruban RH, Kern SE. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res. 2004 Feb 1;64(3):871-5. abstract
Nichols LS, Ashfaq R, Iacobuzio-Donahue CA. Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. Am J Clin Pathol. 2004 Feb;121(2):226-30. abstract
Rogers CD, van der Heijden MS, Brune K, Yeo CJ, Hruban RH, Kern SE, Goggins M. The genetics of FANCC and FANCG in familial pancreatic cancer. Cancer Biol Ther. 2004 Feb;3(2):167-9. abstract
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50. abstract
Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003 Dec 15;63(24):8614-22. abstract
Matsubayashi H, Fukushima N, Sato N, Brune K, Canto M, Yeo CJ, Hruban RH, Kern SE, Goggins M. Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. Cancer Biol Ther. 2003 Nov-Dec;2(6):652-5. abstract
House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ. Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms. Surgery. 2003 Dec;134(6):902-8; discussion 909. abstract
Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M. p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol. 2003 Dec;27(12):1495-501. abstract
Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res. 2003 Nov 1;63(21):7032-7. abstract
Rahman A, Maitra A, Ashfaq R, Yeo CJ, Cameron JL, Hansel DE. Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasms. Am J Clin Pathol. 2003 Nov;120(5):685-90. abstract
Abraham SC, Cruz-Correa M, Argani P, Furth EE, Hruban RH, Boitnott JK. Diffuse lymphoplasmacytic chronic cholecystitis is highly specific for extrahepatic biliary tract disease but does not distinguish between primary and secondary sclerosing cholangiopathy. Am J Surg Pathol. 2003 Oct;27(10):1313-20. abstract
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003 Oct 23;425(6960):846-51. abstract
Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayashi H, Iacobuzio-Donahue CA, Rosty C, Goggins M. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 2003 Jul 15;63(14):4158-66. abstract
Hansel DE, Rahman A, Hermans J, de Krijger RR, Ashfaq R, Yeo CJ, Cameron JL, Maitra A. Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression. Mod Pathol. 2003 Jul;16(7):652-9. abstract
Hempen PM, Kurpad H, Calhoun ES, Abraham S, Kern SE. A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. Hum Mutat. 2003 Apr;21(4):445. abstract
Iacobuzio-Donahue CA, Maitra A, Olsen M, Lowe AW, Van Heek NT, Rosty
C, Walter K, Sato N, Parker A, Ashfaq R, Jaffee E, Ryu B, Jones J,
Eshleman JR, Yeo CJ, Cameron JL, Kern SE, Hruban RH, Brown PO, Goggins M.
Exploration of global gene expression patterns in pancreatic
adenocarcinoma using cDNA microarrays. Am J Pathol. 2003
Apr;162(4):1151-62.
abstract
Hansel DE, Kern SE, Hruban RH. Molecular pathogenesis of pancreatic
cancer. Annu Rev Genomics Hum Genet. 2003;4:237-56.
abstract
Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen
PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE. BRAF and FBXW7 (CDC4, FBW7,
AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential
therapeutic targets. Am J Pathol. 2003 Oct;163(4):1255-60. abstract
House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Lillemoe KD,
Cameron JL, Hruban RH, Maitra A, Yeo CJ. Aberrant hypermethylation of
tumor suppressor genes in pancreatic endocrine neoplasms. Ann Surg. 2003
Sep;238(3):423-31; discussion 431-2.
abstract
Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron
JL, Yeo CJ, Hruban RH. Multicomponent analysis of the pancreatic
adenocarcinoma progression model using a pancreatic intraepithelial
neoplasia tissue microarray. Mod Pathol. 2003 Sep;16(9):902-12.
abstract
McCarthy DM, Maitra A, Argani P, Rader AE, Faigel DO, Van Heek NT,
Hruban RH, Wilentz RE. Novel markers of pancreatic adenocarcinoma in
fine-needle aspiration: mesothelin and prostate stem cell antigen labeling
increases accuracy in cytologically borderline cases. Appl Immunohistochem
Mol Morphol. 2003 Sep;11(3):238-43.
abstract
Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH,
Hruban RH, Goggins M. SPARC/osteonectin is a frequent target for aberrant
methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal
interactions. Oncogene. 2003 Aug 7;22(32):5021-30.
abstract
Montgomery E, Wilentz RE, Argani P, Fisher C, Hruban RH, Kern SE,
Lengauer C. Analysis of anaphase figures in routine histologic sections
distinguishes chromosomally unstable from chromosomally stable
malignancies. Cancer Biol Ther. 2003 May-Jun;2(3):248-52.
abstract
Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli
A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM. Identifying
tumor origin using a gene expression-based classification map. Cancer Res.
2003 Jul 15;63(14):4144-9.
abstract
Fukushima N, Sato N, Sahin F, Su GH, Hruban RH, Goggins M. Aberrant
methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in
pancreatic ductal neoplasms. Br J Cancer. 2003 Jul 21;89(2):338-43.
abstract
Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins
M, Hruban RH, Su GH. Loss of Stk11/Lkb1 expression in pancreatic and
biliary neoplasms. Mod Pathol. 2003 Jul;16(7):686-91.
abstract
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue
CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW,
Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in
epithelial differentiation during pancreatic tumorigenesis. Cancer Cell.
2003 Jun;3(6):565-76.
abstract
Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL,
Hruban RH, Goggins M. Discovery of novel targets for aberrant methylation
in pancreatic carcinoma using high-throughput microarrays. Cancer Res.
2003 Jul 1;63(13):3735-42.
abstract
Hardacre JM, Iacobuzio-Donahue CA, Sohn TA, Abraham SC, Yeo CJ,
Lillemoe KD, Choti MA, Campbell KA, Schulick RD, Hruban RH, Cameron JL,
Leach SD. Results of pancreaticoduodenectomy for lymphoplasmacytic
sclerosing pancreatitis. Ann Surg. 2003 Jun;237(6):853-8; discussion
858-9.
abstract
van der Heijden MS, Yeo CJ, Hruban RH, Kern SE. Fanconi anemia gene
mutations in young-onset pancreatic cancer. Cancer Res. 2003 May
15;63(10):2585-8.
abstract
Adsay NV, Merati K, Nassar H, Shia J, Sarkar F, Pierson CR, Cheng JD,
Visscher DW, Hruban RH, Klimstra DS. Pathogenesis of colloid (pure
mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin
(MUC2) production with altered cell polarity and abnormal cell-stroma
interaction may be the key factor in the morphogenesis and indolent
behavior of colloid carcinoma in the breast and pancreas. Am J Surg
Pathol. 2003 May;27(5):571-8.
abstract
Iacobuzio-Donahue CA, Hruban RH. Gene expression in neoplasms of the
pancreas: applications to diagnostic pathology. Adv Anat Pathol. 2003
May;10(3):125-34.
abstract
Matsubayashi H, Sato N, Fukushima N, Yeo CJ, Walter KM, Brune K, Sahin
F, Hruban RH, Goggins M. Methylation of cyclin D2 is observed frequently
in pancreatic cancer but is also an age-related phenomenon in
gastrointestinal tissues. Clin Cancer Res. 2003 Apr;9(4):1446-52.
abstract
Fukushima N, Walter KM, Uek T, Sato N, Matsubayashi H, Cameron JL,
Hruban RH, Canto M, Yeo CJ, Goggins M. Diagnosing pancreatic cancer using
methylation specific PCR analysis of pancreatic juice. Cancer Biol Ther.
2003 Jan-Feb;2(1):78-83.
abstract
McCarthy DM, Hruban RH, Argani P, Howe JR, Conlon KC, Brennan MF,
Zahurak M, Wilentz RE, Cameron JL, Yeo CJ, Kern SE, Klimstra DS. Role of
the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater:
analysis of 140 cases. Mod Pathol. 2003 Mar;16(3):272-8.
abstract
Abraham SC, Cruz-Correa M, Argani P, Furth EE, Hruban RH, Boitnott JK.
Lymphoplasmacytic chronic cholecystitis and biliary tract disease in
patients with lymphoplasmacytic sclerosing pancreatitis. Am J Surg Pathol.
2003 Apr;27(4):441-51.
abstract
Hempen PM, Zhang L, Bansal RK, Iacobuzio-Donahue CA, Murphy KM, Maitra
A, Vogelstein B, Whitehead RH, Markowitz SD, Willson JK, Yeo CJ, Hruban
RH, Kern SE. Evidence of selection for clones having genetic inactivation
of the activin A type II receptor (ACVR2) gene in gastrointestinal
cancers. Cancer Res. 2003 Mar 1;63(5):994-9.
abstract
Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK,
Albores-Saavedra J, Hruban RH. Eosinophilic pancreatitis and increased
eosinophils in the pancreas. Am J Surg Pathol. 2003 Mar;27(3):334-42.
abstract
Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O,
Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH,
Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R.
Identification of CDH1 germline missense mutations associated with
functional inactivation of the E-cadherin protein in young gastric cancer
probands. Hum Mol Genet. 2003 Mar 1;12(5):575-82.
abstract
Petersen GM, Hruban RH. Familial pancreatic cancer: where are we in
2003? J Natl Cancer Inst. 2003 Feb 5;95(3):180-1. No abstract available.
Nguyen TC, Sohn TA, Cameron JL, Lillemoe KD, Campbell KA, Coleman J,
Sauter PK, Abrams RA, Hruban RH, Yeo CJ. Standard vs. radical
pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective,
randomized trial evaluating quality of life in pancreaticoduodenectomy
survivors. J Gastrointest Surg. 2003 Jan;7(1):1-9; discussion 9-11.
abstract
Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK,
Hruban RH. Pancreaticoduodenectomy (Whipple resections) in patients
without malignancy: are they all 'chronic pancreatitis'? Am J Surg Pathol.
2003 Jan;27(1):110-20.
abstract
Rosty C, Goggins M. Early detection of pancreatic carcinoma. Hematol
Oncol Clin North Am. 2002 Feb;16(1):37-52.
abstract
Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M,
Cameron JL, Wu TT, Hruban RH. Solid-pseudopapillary tumors of the
pancreas are genetically distinct from pancreatic ductal adenocarcinomas
and almost always harbor beta-catenin mutations. Am J Pathol. 2002
Apr;160(4):1361-9.
abstract
Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, Brennan M,
Cameron JL, Klimstra DS. Genetic and immunohistochemical analysis of
pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p
and alterations in the APC/beta-catenin pathway. Am J Pathol. 2002
Mar;160(3):953-62.
abstract
Adsay NV, Merati K, Andea A, Sarkar F, Hruban RH, Wilentz RE, Goggins
M, Iocobuzio-Donahue C, Longnecker DS, Klimstra DS. The dichotomy in the
preinvasive neoplasia to invasive carcinoma sequence in the pancreas:
differential expression of MUC1 and MUC2 supports the existence of two
separate pathways of carcinogenesis. Mod Pathol. 2002 Oct;15(10):1087-95.
abstract
Yeo TP, Hruban RH, Leach SD, Wilentz RE, Sohn TA, Kern SE,
Iacobuzio-Donahue CA, Maitra A, Goggins M, Canto MI, Abrams RA, Laheru D,
Jaffee EM, Hidalgo M, Yeo CJ. Pancreatic cancer. Curr Probl Cancer. 2002
Jul-Aug;26(4):176-275.
full article
Tascilar M, van Rees BP, Sturm PD, Tytgat GN, Hruban RH, Goodman SN,
Giardiello FM, Offerhaus GJ, Tersmette AC. Pancreatic cancer after
remote peptic ulcer surgery. J Clin Pathol. 2002 May;55(5):340-5. abstract
Ueki T, Walter KM, Skinner H, Jaffee E, Hruban RH, Goggins M. Aberrant
CpG island methylation in cancer cell lines arises in the primary cancers
from which they were derived. Oncogene. 2002 Mar 27;21(13):2114-7.
abstract
van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, Cameron JL,
Offerhaus GJ, Hicks JL, Wilentz RE, Goggins MG, De Marzo AM, Hruban RH,
Maitra A. Telomere shortening is nearly universal in pancreatic
intraepithelial neoplasia. Am J Pathol. 2002 Nov;161(5):1541-7.
abstract
van Heek T, Rader AE, Offerhaus GJ, McCarthy DM, Goggins M, Hruban RH,
Wilentz RE. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle
aspirates of the pancreas: a molecular panel correlates with and
supplements cytologic diagnosis. Am J Clin Pathol. 2002 May;117(5):755-65.
abstract
Fukushima N, Sato N, Ueki T, Rosty C, Walter KM, Wilentz RE, Yeo CJ,
Hruban RH, Goggins M. Aberrant methylation of preproenkephalin and p16
genes in pancreatic intraepithelial neoplasia and pancreatic ductal
adenocarcinoma. Am J Pathol. 2002 May;160(5):1573-81.
abstract
Iacobuzio-Donahue CA, Ryu B, Hruban RH, Kern SE. Exploring the host
desmoplastic response to pancreatic carcinoma : gene expression of stromal
and neoplastic cells at the site of primary invasion. Am J Pathol
160:91-9, 2002.
abstract
Jaffee EM, Hruban RH, Canto M, Kern SE. Focus on pancreas cancer.
Cancer Cell. 2002 Jul;2(1):25-8. No abstract available.
Klein AP, Beaty TH, Bailey-Wilson JE, Brune KA, Hruban RH, Petersen
GM. Evidence for a major gene influencing risk of pancreatic cancer.
Genet Epidemiol. 2002 Aug;23(2):133-49.
abstract
Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation
between proliferative activity and dysplasia in pancreatic intraepithelial
neoplasia (PanIN): additional evidence for a recently proposed model of
progression. Mod Pathol. 2002 Apr;15(4):441-7.
abstract
Maitra A, Ashfaq R, Gunn CR, Rahman A, Yeo CJ, Sohn TA, Cameron JL,
Hruban RH, Wilentz RE. Cyclooxygenase 2 expression in pancreatic
adenocarcinoma and pancreatic intraepithelial neoplasia: an
immunohistochemical analysis with automated cellular imaging. Am J Clin
Pathol. 2002 Aug;118(2):194-201.
abstract
Maitra A, Iacobuzio-Donahue C, Rahman A, Sohn TA, Argani P, Meyer R,
Yeo CJ, Cameron JL, Goggins M, Kern SE, Ashfaq R, Hruban RH, Wilentz RE.
Immunohistochemical validation of a novel epithelial and a novel stromal
marker of pancreatic ductal adenocarcinoma identified by global expression
microarrays: sea urchin fascin homolog and heat shock protein 47. Am J
Clin Pathol. 2002 Jul;118(1):52-9.
abstract
Movahedi-Lankarani S, Hruban RH, Westra WH, Klimstra DS. Primitive
neuroectodermal tumors of the pancreas: a report of seven cases of a rare
neoplasm. Am J Surg Pathol. 2002 Aug;26(8):1040-7.
abstract
Murphy KM, Brune KA, Griffin C, Sollenberger JE, Petersen GM, Bansal
R, Hruban RH, Kern SE. Evaluation of candidate genes MAP2K4, MADH4,
ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2
mutations in 17%. Cancer Res. 2002 Jul 1;62(13):3789-93.
abstract
Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan
DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M.
Identification of
hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a
biomarker for pancreatic ductal adenocarcinoma by protein biochip
technology. Cancer Res. 2002 Mar 15;62(6):1868-75.
abstract
Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, Hruban RH,
Goggins M. Overexpression of S100A4 in pancreatic ductal adenocarcinomas
is associated with poor differentiation and DNA hypomethylation. Am J
Pathol 160:45-50, 2002.
(abstract)
Sato N, Ueki T, Fukushima N, Iacobuzio-Donahue CA, Yeo CJ, Cameron JL,
Hruban RH, Goggins M. Aberrant methylation of CpG islands in intraductal
papillary mucinous neoplasms of the pancreas. Gastroenterology. 2002
Jul;123(1):365-72.
abstract
Seidel G, Zahurak M, Iacobuzio-Donahue C, Sohn TA, Adsay NV, Yeo CJ,
Lillemoe KD, Cameron JL, Hruban RH, Wilentz RE. Almost all infiltrating
colloid carcinomas of the pancreas and periampullary region arise from in
situ papillary neoplasms: a study of 39 cases. Am J Surg Pathol. 2002
Jan;26(1):56-63.
abstract
Swartz MJ, Batra SK, Varshney GC, Hollingsworth MA, Yeo CJ, Cameron
JL, Wilentz RE, Hruban RH, Argani P. MUC4 expression increases
progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol.
2002 May;117(5):791-6.
abstract
Yeo CJ, Cameron JL, Lillemoe KD, Sohn TA, Campbell KA, Sauter PK,
Coleman J, Abrams RA, Hruban RH. Pancreaticoduodenectomy with or without
distal gastrectomy and extended retroperitoneal lymphadenectomy for
periampullary adenocarcinoma, part 2: randomized controlled trial
evaluating survival, morbidity, and mortality. Ann Surg. 2002
Sep;236(3):355-66; discussion 366-8.
abstract
Tersmette AC, Petersen GM, Offerhaus GJ, Falatko FC, Brune KA, Goggins
M, Rozenblum E, Wilentz RE, Yeo CJ, Cameron JL, Kern SE, Hruban RH.
Increased risk of incident pancreatic cancer among first-degree relatives
of patients with familial pancreatic cancer. Clin Cancer Res 7:738-44,
2001.
(abstract) |
(full text)
Tobi M, Hatfield J, Adsay V, Galagan K, Kozarek R, Inagaki M, Kasai S,
Tokusashi Y, Obara T, Hruban RH, Lough J, Barkun AN, Jabbari M, Sheikh R,
Ruebner B, Lawson MJ, Ben-Josef E, Fligiel S. Prognostic significance of
the labeling of Adnab-9 in pancreatic intraductal papillary mucinous
neoplasms. Int J Pancreatol. 2001;29(3):141-50.
abstract
Ueki T, Toyota M, Skinner H, Walter KM, Yeo CJ, Issa JP, Hruban RH,
Goggins M. Identification and characterization of differentially
methylated CpG islands in pancreatic carcinoma. Cancer Res 61:8540-6,
2001.
(abstract)
Argani P, Iacobuzio-Donahue C, Ryu B, Rosty C, Goggins M, Wilentz RE,
Murugesan SR, Leach SD, Jaffee E, Yeo CJ, Cameron JL, Kern SE, Hruban RH.
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas
of the pancreas: identification of a new pancreatic cancer marker by
serial analysis of gene expression (SAGE). Clin Cancer Res 7:3862-8, 2001.
(abstract)
Argani P, Rosty C, Reiter RE, Wilentz RE, Murugesan SR, Leach SD, Ryu
B, Skinner HG, Goggins M, Jaffee EM, Yeo CJ, Cameron JL, Kern SE, Hruban
RH. Discovery of new markers of cancer through serial analysis of gene
expression: prostate stem cell antigen is overexpressed in pancreatic
adenocarcinoma. Cancer Res 61:4320-4324, 2001.
(abstract) |
(full text)
Hruban RH. Pancreatic cancer: from genes to patient care. J
Gastrointest Surg. 2001 Nov-Dec;5(6):583-7. Review.
Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES,
Goodman SN, Kern SE, Klimstra DS, Kloppel G, Longnecker DS, Luttges J,
Offerhaus GJ. Pancreatic intraepithelial neoplasia: a new nomenclature and
classification system for pancreatic duct lesions. Am J Surg Pathol. 2001
May;25(5):579-86.
abstract
Hruban RH, Canto MI, Yeo CJ. Prevention of pancreatic cancer and
strategies for management of familial pancreatic cancer. Dig Dis.
2001;19(1):76-84.
abstract
Jaffee EM, Hruban RH, Biedrzycki B, Laheru D, Schepers K, Sauter PR,
Goemann M, Coleman J, Grochow L, Donehower RC, Lillemoe KD, O'Reilly S,
Abrams RA, Pardoll DM, Cameron JL, Yeo CJ. Novel allogeneic
granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine
for pancreatic cancer: a phase i trial of safety and immune activation. J
Clin Oncol 19:145-56, 2001.
abstract
Jones JB, Song JJ, Hempen PM, Parmigiani G, Hruban RH, Kern SE.
Detection of mitochondrial DNA mutations in pancreatic cancer offers a
"mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res
2001 Feb 15;61(4):1299-304.
abstract
Kern S, Hruban R, Hollingsworth MA, Brand R, Adrian TE, Jaffee E,
Tempero MA. A white paper: the product of a pancreas cancer think tank.
Cancer Res. 2001 Jun 15;61(12):4923-32.
abstract
McCarthy DM, Brat DJ, Wilentz RE, Yeo CJ, Cameron JL, Kern SE, Hruban
RH. Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma:
analysis of progression and recurrence by DPC4 immunohistochemical
labeling. Hum Pathol. 2001 Jun;32(6):638-42.
abstract
Ryu B, Jones J, Hollingsworth MA, Hruban RH, Kern SE.
Invasion-specific genes in malignancy: serial analysis of gene expression
comparisons of primary and passaged cancers.
Cancer Res 61: 1833-1838, 2001. abstract
Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL,
Iacobuzio-Donahue CA, Hruban RH, Goggins M. STK11/LKB1 Peutz-Jeghers
gene inactivation in intraductal papillary-mucinous neoplasms of the
pancreas. Am J Pathol 159:2017-22, 2001.
abstract
Smith AE, Levi AW, Nadasdy T, Campbell KA, Fishman EK, Hruban RH. The
pigmented "black" neuroendocrine tumor of the pancreas: a question of
origin. Cancer. 2001 Oct 1;92(7):1984-91.
abstract
Sohn TA, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Lillemoe
KD. Intraductal papillary mucinous neoplasms of the pancreas: an
increasingly recognized clinicopathologic entity. Ann Surg. 2001
Sep;234(3):313-21.
abstract
Su GH, Bansal R, Murphy KM, Montgomery E, Yeo CJ, Hruban RH, Kern SE.
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic
carcinoma. Proc Natl Acad Sci USA 98:3254-7, 2001.
abstract
Tascilar M, Offerhaus GJ, Altink R, Argani P, Sohn TA, Yeo CJ, Cameron
JL, Goggins M, Hruban RH, Wilentz RE. Immunohistochemical labeling for
the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy
specimens of the pancreas and bile duct. Am J Clin Pathol 116:831-7,
2001.
(abstract)
Hilgers W, Koerkamp BG, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern
SE. Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the
pancreas. Genes Chromosomes Cancer. 2000 Mar;27(3):239-43.
abstract
Hilgers W, Song JJ, Haye M, Hruban RR, Kern SE, Fearon ER. Homozygous
deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of
pancreatic and biliary cancers. Genes Chromosomes Cancer. 2000
Apr;27(4):353-7.
abstract
Huang JJ, Yeo CJ, Sohn TA, Lillemoe KD, Sauter PK, Coleman J, Hruban
RH, Cameron JL. Quality of life and outcomes after
pancreaticoduodenectomy. Ann Surg. 2000 Jun;231(6):890-8.
abstract
Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Argani P,
Sohn TA, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Dpc-4 protein is
expressed in virtually all human intraductal papillary mucinous neoplasms
of the pancreas: comparison with conventional ductal adenocarcinomas. Am J
Pathol. 2000 Sep;157(3):755-61.
abstract
Iacobuzio-Donahue CA, Wilentz RE, Argani P, Yeo CJ, Cameron JL, Kern
SE, Hruban RH. Dpc4 protein in mucinous cystic neoplasms of the
pancreas: frequent loss of expression in invasive carcinomas suggests a
role in genetic progression. Am J Surg Pathol. 2000 Nov;24(11):1544-8.
abstract
Sohn TA, Campbell KA, Pitt HA, Sauter PK, Coleman JA, Lillemo KD, Yeo
CJ, Cameron JL. Quality of life and long-term survival after surgery for
chronic pancreatitis. J Gastrointest Surg 4:355-365, 2000. abstract
Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, Sauter
PK, Coleman J, Hruban RH, Lillemoe KD. Resected adenocarcinoma of the
pancreas-616 patients: results, outcomes, and prognostic indicators. J
Gastrointest Surg. 2000 Nov-Dec;4(6):567-79.
abstract
St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E,
Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed
in human tumor endothelium. Science 289:1121-2,2000.
abstract
van den Berg W, Tascilar M, Offerhaus GJ, Albores-Saavedra J, Wenig
BM, Hruban RH, Gabrielson E. Pancreatic mucinous cystic neoplasms with
sarcomatous stroma: molecular evidence for monoclonal origin with
subsequent divergence of the epithelial and sarcomatous components. Mod
Pathol. 2000 Jan;13(1):86-91.
abstract
Wilentz RE, Albores-Saavedra J, Hruban RH. Mucinous cystic neoplasms
of the pancreas. Semin Diagn Pathol. 2000 Feb;17(1):31-42.
Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, Sohn TA, Kadkol
SS, Yeo CJ, Choti M, Zahurak M, Johnson K, Tascilar M, Offerhaus GJ,
Hruban RH, Kern SE. Genetic, immunohistochemical, and clinical features
of medullary carcinoma of the pancreas: A newly described and
characterized entity. Am J Pathol 156:1641-1651,2000.
abstract
Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL,
Yeo CJ, Kern SE, Hruban RH. Loss of expression of Dpc4 in pancreatic
intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in
neoplastic progression. Cancer Res 60:2002-2006, 2000. abstract
Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern
SE, Hruban RH. Immunohistochemical labeling for dpc4 mirrors genetic
status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.
Am J Pathol 156:37-43, 2000.
abstract
Sturm PD, Baas IO, Clement MJ, Nakeeb A, Offerhaus JGA, Hruban RH,
Pitt HA. Alterations of the p53 tumor-suppressor gene in K-ras oncogene in
perihilar cholangiocarcinomas from a high-incidence area. Int J Cancer
78(6):695-8, 1998.
abstract
