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Nagaraj, S., Gupta, K., Pisarev,V., Kinarsky, L., Sherman, S., Loveleen, K., Herber, D., Schneck, J.P., and Gabrilovich, D. Altered recognition of antigen is a mechanism of CD8+T cell tolerance in cancer. Nature Medicine 13, 2007: 828-835. Download PDF
Mohamood , A.S., Guler, M.L., Xiao, Z., Zheng, D., Hess, A., Wang, Y., Yagita, H., Schneck, J.P., Hamad, A.R. Protection from autoimmune diabetes and T-Cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically. Am J Pathol. 2007 Jul; 171(1):97-106. Download PDF
Fahmy,T., Schneck ,J.P., Saltzman, W. A nanoscopic multivalent antigen-presenting carrier for sensitive detection and drug delivery to T Cells. Nanomedicine .2007Mar;3(1)75-85.
Deviren, G., Gupta, K., Paulaitis, M.E., Schneck, J.P. Detection of Antigen–Specific T cells on p/MHC Microarrays. J. Mol. Recognit. 2007Jan-Feb:20(1):32-8; Aug 11 Pub.Online 9 Nov 2006. Download PDF
Mohamood, A.S., Trujillo, C.J., Zheng, D., Jie, C., Martinez, M.F., Schneck, J.P., Hamad, A.R.A. Gld mutation of Fas ligand increases the frequency and up-Regulates Cell survival genes in CD25+CD4+ TR cells. Int. Immunol. 2006 Jun 12; [Epub ahead of print]. Download PDF
Boin F. Wigley FM, Schneck J.P.,Oelke M., Rosen A. Evaluation of topoisomerase-1- specific CD8+ T-cell response in systematic sclerosis. Ann NY Acad Sci. 2005; Dec;1062:137-45.
Oelke, M., Krueger, C., Giuntoli, R.L., II, Schneck, J.P. Artificial antigen-presenting cells: artificial solutions for real diseases. Trends in Molecular Medicine 2005; 11:412-420. Download PDF
Karabekian, Z., Simon, D., Lytton, Silver, P.B., Sergeev, Y., Schneck, J.P., and Caspi, R.R. Antigen/MHC class II/Ig dimmers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules. Investigative Ophthalmology & Visual Scienc, 2005; 46:3769-3776. Download PDF
Oelke, M., Krueger, C., and Schneck, J. P. Technological advances in adoptive immunotherapy. Drugs of Today 2005; 41:13-21. Download PDF
Technological advances in adoptive immunotherapy. Mathias Oelke, Christine Krueger and Jonathan P. Schneck. Drugs of Today, 41:13-21, 2005. Download PDF
Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck. Sirianni N, Ha PK, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP, DeLeo A, Ferris RL. Clin Cancer Res. 10:6929-37, 2004. Download PDF
Immunotherapy with enhanced self immune cells. Mathias Oelke and Jonathan Schneck. Discovery Medicine, 4:203-207, 2004. Download PDF
Quality and quantity: New strategies to improve immunotherapy of cancer. Krueger C, Schneck JP and Oelke M. Trends in Molecular Medicine 10:205-208, 2004. Download PDF
HLA-Ig based artificial Antigen-presenting cells: Setting the terms of engagement. Mathias Oelke and Jonathan P. Schneck. Clinical Immunology 10:243-251. 2004. Download PDF
B220+ DN T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production. Hamad AR, Mohamood AS, Trujillo CJ, Huang C-T, Yuan E and JP Schneck. J. Immunol. 171:2421-2426, 2003. Download PDF
Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig coated artificial Antigen Presenting Cells. Oelke M, Maus MV, Didiano D, June CH, Mackensen A, and Schneck JP. Nature Medicine, 9:619-624, 2003. Download PDF
Peptide-b2-microglobulin-MHC fusion molecules bind antigen-specific T cells and can be used for multivalent MHC-Ig complexes. Greten TF, Korangy F, Neumann G, Wedemeyer H, Schlote K, Heller A, Scheffer S, Pardoll DM, Garbe AI, Schneck JP, Manns MP. J Immunol Methods, 271:125-135, 2002. Download PDF
Probing T cell membrane organization using dimeric MHC-Ig complexes. Fahmy T, Bieler J, Schneck J. J Immunol Methods. 2002 Oct 1;268(1):93. Download PDF
T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Brehm MA, Pinto AK, Daniels KA, Schneck JP, Welsh RM, Selin LK. Nat Immunol. 2002 Jul;3(7):627-34.
Development and use of multimeric major histocompatibility complex molecules. Greten TF, Schneck JP. Clin Diagn Lab Immunol 2002 Mar;9(2):216-20, 2002. Download PDF
Antigen-induced T cell death is regulated by CD4 expression. Hamad AR, Schneck JP. Int Rev Immunol 2001 Oct;20(5):535-46. 2001
Antigen-specific blockade of t cells in vivo using dimeric mhc peptide. O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. J Immunol 167(5):2555-2560, 2001. Download PDF
Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity. Hamad AR, Srikrishnan A, Mirmonsef P, Broeren CP, June CH, Pardoll D, Schneck JP. J Exp Med 193(10):1113-1121, 2001. Download PDF
Activation induced death of T cell regulated by CD4 coreceptor. AR Hamad and J. Schneck. Intern Rev Immunol 20:1-12, 2001.
Increased TcR avidity after T cell activation: A mechanism for sensing low density antigen. Fahmy, T., Bieler, J.G., Edidin, M., and Schneck, J.P. Immunity 14, 135-143, 2001, Cover Article. Download PDF
Enhanced Immunogenicity of CTL Epitope Analogues Derived from Positional Scanning Synthetic Combinatorial Libraries. La Rosa, C., Krishnan, R., Papp, J., Gardner, A., Markel, S., Mead, J Schneck, J.P., Houghten, R., Pinilla, C., and Diamond, D.J. Blood. 97:1776-1786, 2001. Download PDF
Increased activated HTLV-I Tax11-19-specific CD8+ cells in patients with HTLV-I-associated myelopathy/Tropical spastic paraparesis: Correlation with HTLV-I proviral load. Nagai, M., Ryuji, R., Greten, T.F., Schneck, J.P., Leist, L.P. and Jacobson, S. J. Infectious Diseases 183:197-205, 2001. Download PDF
Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex. Slansky, J.E., Rattis, F.M., Boyd, L.F., Fahmy, T., Jaffee, E.M., Schneck, J.P., Margulies, D.H., and Pardoll, D.M. Immunity 13:529-538, 2000. Download PDF
Monitoring Antigen-Specific T Cells Using MHC-Ig Dimers. Schneck, J.P., Immunol. Invest. 29:163-169, 2000.
Monitoring Antigen-Specific T Cells Using MHC-Ig Dimers. Schneck, J.P., Slansky, J.E., O'Herrin, M.O., and Greten, T.F. Current Protocols of Immunological Techniques Supplement 35:17.0.1-17.0.2 & 17.2.1-17.2.17.
Monitoring Antigen-Specific T Cells Using MHC-Ig Dimers. Schneck, J.P., Immunol. Invest. 29:163-169, 2000.
Lateral Diffusion of GFP-Tagged H2Ld Molecules and of GFP-TAP 1 Reports on the Assembly and Retention of these Molecules in the Endoplasmic Reticulum. Marguet, D., Spiliotis, E.T., Pentcheva, T., Lebowitz, M., Schneck, J., and Edidin, M. Immunity, 11:231-240, 1999. PDF Version
The Major Histocompatibility Complex Leads the Way for Disease-Linked into the Clinic. Howard, M., Spack, E.G., Choudhury, K., Greten, T.F., and Schneck, J.P. Immunol. Today, 20:161-165, 1999.
Soluble, High-Affinity Dimers of T-Cell Receptors and Class II Major Histocompatibility: Biochemical Probes for Analysis and Modulation of Immune Responses. Lebowitz, M. S., O'Herrin, S.M., Hamad, A.-R., Fahmy, T., Marguet, D., Barnes, N. B., Pardoll, D., Bieler, J. G., and Schneck, J. P. Cellular Immunology, 192:175-184, 1999. PDF Version
An Algorithm for Evaluating Human Cytotoxic T Lymphocyte Responses to Candidate AIDS Vaccines. Carruth, L.M., Greten, T.F., Murray, C.E., Castro, M.G., Crone, S. N., Pavlat, W., Schneck, J., and Siliciano, R. F. AIDS Res. and Human Retro. 15:1021-1034, 1999. PDF Version
Direct Analysis of Viral-Specific CD8+ T Cells with Soluble HLA-A2/Tax11-19 Tetramer Complexes in Patients with Human T Cell Lymphotropic Virus-Associated Myelopathy. Bieganowska K, Hollsberg P, Buckle GJ, Lim DG, Greten TF, Schneck J, Altman JD, Jacobson S, Ledis SL, Hanchard B, Chin J, Morgan O, Roth PA, Hafler DA. J Immunol 162:1765-1771, 1999. PDF Version
Potent T Cell Activation with Dimeric Peptide-MHC Class II Ligand: The Role of CD4 Coreceptor. Hamad, A.R.A., O'Herrin, S., Lebowitz, M., Srikrishnan, A., Bieler, J., Schneck, J., and Pardoll, D. JEM 188:1633-1640, 1998. PDF Version
Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19 specific CD8+ T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Greten, T. F., Slansky, J. E., Kubota, R., Soldan, S. S., Jaffee, E. M., Leist, T. P., Pardoll, D. M., Jacobson, S., and Schneck, J. P. PNAS 95:7568-7573, 1998. PDF Version
Analysis of the expression of peptide-major histocompatability complexes using high affinity soluble divalent T cell receptors. O'Herrin, S. M., Lebowitz, M. S., Bieler, J. G. , Al-Ramadi, B., Utz, U., Bothwell, A., and Schneck, J. J. Exp. Med. 186 (8);1333-1345, 1997. PDF Version
Differential Effects of B Cell Receptor and B Cell Receptor-FcgRIIB1 Engagement on Docking of Csk to GAP-associated p62. Vuica, M., Desiderio, S. and Schneck, J. P. J. Exp. Med. 186 (2):259-267, 1997. PDF Version
Peptide binding to MHC class I is determined by individual pockets in the binding groove. Johansen, T. E., McCullough, K., Catipovic, B., Su, X.-M., Amzel, M. and Schneck, J. Scand. J. Immunol. 46:137-146, 1997.
Expression of human recombinant b2 microglobulin by Aspergillus nidulans and its activity. O'Herrin, S. M., Kulkarni, S., Kenealy, W. R., Fechner Jr., J. H., Sollinger, H., Schneck, J. P., and Burlingham, W. J. Human Immunol. 50: 63-72, 1996.
Csk associates with the TCR d and e chains via its SH2 domain. Rafnar, T., Schneck, J. P., Brummet, M. E., Marsh, D.,G., and Catipovic, B. Ann NY Acad. Sci. 766:206-8, 1995 Sept. 7. PDF Version
Csk associates with the TCR d and e chains via its SH2 domain: A mechanism for turning off TCR signalling. Catipovic, B., Schneck, J. P., Brummet, M. E., Marsh, D. G., and Rafnar, T.. Journal Biol.Chem. 271(16) 9698-9703, 1996.
Abnormal B-cell function in HTLV-I-tax transgenic mice. Peebles, S., Maliszewski, C. R., Sato, T. A., Hyde, J., Maroulakou, I. G., Huziker, R., Schneck, J., and Green, J. R. Oncogene 10 (6): 1045-51, 1995 Mar. 16.
Analysis of the structure of empty and peptide-loaded MHC molecules at the cell surface. Catipovic, B.C., Talluri, G., Oh, J., Wei, T., Su, X.-M., Johansen, T E., Edidin, M., and Schneck, J. P. J. Exp. Med. 180:1753-1761, 1994.
A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Dal Porto, J., Johansen, T.E., Catipovic, B.C., Parfitt, D.-J.,Tuveson, D., Gether, U., Kozlowski, S., Fearon, D., and Schneck, J. PNAS 90:6671-6675, 1993.
Role of conserved regions of class I MHC molecules in the activation of CD8+ CTL by peptide and purified cell-free class I molecules. Takeshita, T., Kozlowski, S., England, R.D., Brower, R., Schneck, J., Takahashi, H., DeLisi, C., Margulies, D.H. and Berzofsky, J.A. Intern. Immunol. 5:1129-1138, 1993.
Major histocompatibility complex conformational epitopes are peptide specific. Catipovic, B., Dal Porto, J., Mage, M., Johansen, T.E., and Schneck, J.P. JEM 176, 1611-1618, 1992
CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma. Blok, R., Margulies, D.H., Pease, L., Ribaudo, R.K., Schneck, J., and McCluskey, J. Inter. Immunol. 4;455-66, 1992.
Immunochemical analysis of a recombinant, genetically engineered, secreted HLA-A2/Q10b fusion protein. DeVito, L.D., Mason, B., Schneck, J., Margulies, D.H., Sollinger, H.W., and Burlingham, W.J. Human Immunol. 32:125-133, 1991.
Multivalent requirement for the stimulation of alloreactive T cells: Studies with engineered soluble MHC class I proteins in vitro and in vivo. Margulies, D.H., Boyd, L.F., Kozlowski, S., Kjer-Nielson, L., Lopez, R., McCluskey, J., Schneck, J., and Hunziker, R. In: Transgenic Mice and Mutants in MHC Research. David, C. and Egorov, I. (eds.) Springer-Verlag, Berlin, pp. 39-45, 1990.
A peptide derived from the alpha helical region of class I MHC blocks CTL engagement of the class I MHC molecule. Munitz, T.I., Schneck, J., Coligan, J.E., Maloy, W.L., Henrich, J.P., Sharrow, S.O., Margulies, D.H., and Singer, A. Cold Spring Harbor Symp. Quant. Biol. 54:557-561, 1989.
Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule. Schneck, J., Munitz, T., Coligan, J.E., Maloy, W.L., Margulies, D.H., and Singer, A. Proc. Natl. Acad. Sci. U.S.A. 86:8516-8520, 1989.
Inhibition of an allospecific T cell hybridoma by soluble class I proteins and peptides: Estimation of the affinity of a T cell receptor for class I MHC molecules. Schneck, J., Maloy, W.L., Coligan, J.E., and Margulies, D.H. Cell. 55:47-53, 1989.
Interaction between interferon and cells of the immune system. Bloom, B.R., Schneck, J., Rager-Zisman, B., Quan, P.C., Neighbour, A., Minato, N., Reid, L., and Rosen, O.M. In: Chemistry and Biology of Interferons: Relationship to Therapeutics - UCLA Symposia on Molecular and Cellular Biology, Vol. XXV. (Merrigan, T.C., and Friedman, R.M., editors). Academic Press, New York. p. 198, 1982.
Genetic analysis of the role of cAMP in mediating effects of interferon. Schneck, J., Rager-Zisman, B., Rosen, O.M., and Bloom, B.R. Proc. Natl. Acad. Sci. U.S.A. 79:1879-1883, 1982.
Trifluperazine inhibits phagocytosis in a macrophage-like cultured cell line. Horwitz, S.B., Chia, G.H., Harracksingh, C., Orlow, S., Pifko-Hirst, S., Schneck, J., Sorba, L., Speaker, M., Wilk, E.W., and Rosen, O.M. J. Cell. Biol. 91:798-802, 1981.
Modulation of Fc-receptor expression and Fc-mediated phagocytosis in variants of a macrophage-like cell line. Schneck, J., Rosen, O., iamond, B., and Bloom, B.R. J. Immunol. 126:745-749, 1981.
Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line. Rosen, N., Piscatello, J., Schneck, J., Muschel, R.J., Bloom, B.R., and Rosen, O. J. Cell. Physiol. 98:125-136, 1979.
Inhibition of plasminogen activator secretion by cyclic AMP in a macrophage-like cell line. Rosen, N., Schneck, J., Bloom, B.R., and Rosen, O. J. Cyclic Nucleotide Res. 5:345-358, 1978.
Genetic approaches to the mechanisms of macrophage functions. Bloom, B.R., Diamond, B., Muschel, R., Rosen, N., Schneck, J., Damiani, G., Rosen, O., and Scharff, M. Fed. Proc. 37:2765-2771, 1978.