|
Research Directions: next
MOLECULAR PATHOLOGY:
• Delineate unique molecular pathways in the developing different types of ovarian carcinoma. Based on our previous molecular and morphological studies, we propose a new classification of ovarian epithelial tumors. Currently, we continue the line by focusing on testing the new hypothesis by profiling the microRNAome, investigating signaling pathways and exploring DNA copy number changes in different types of ovarian serous carcinoma. References: 1-8
• Molecular diagnosis of metastasis of unknown primary site. The purpose is to apply molecular methods to detect malignant effusions and to differential diagnose different types of carcinomas. “Cancer Map” will be generated by the expression profiles of a limited set of markers. References: 9-11
• Detection of circulating plasma DNA in body fluids for cancer detection. Ongoing project includes development of microfluidics/single molecule detection device for future clinical implementation and application (in collaboration with Johns Hopkins Bioengineering Department). Home brew tests will be set up to test the new technologies in cohorts of cancer patients. References: 12-14
• Identify molecular classifiers to predict clinical outcome of advanced stage ovarian serous borderline tumors. This project is in collaboration with Danish Tumor Registry which provides a population based tissue material and clinical follow up information. Reference: 15
• Identify molecular markers that are associated with tumor progression in ovarian cancer using SAGE. Some of the cell surface markers will be selected to generate humanized antibodies for imaging and therapeutic targeting. References: 7, 16-18
|
|
