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Drs. T.-C. Wu & Chien-Fu Hung

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MOST RECENT PUBLICATIONS

The following publications are a compliation of journal and review articles as well as book chapters that highlight advances in our current research and knowledge of vaccines against HPV-associated cervical cancer.

  1. Y.-Y. Lin, H. Alphs, C.-F. Hung, R.B.S. Roden and T.-C. Wu (2007) Vaccines against human papillomavirus. Frontiers in Bioscience 12: 246-64.
  2. H. H. Alphs, T.-C. Wu, R. B.S. Roden (2007) Prevention and treatment of cervical cancer by vaccination. Book Chapter of Molecular Pathology of Gynecologic Cancer, Editors A. Giordano, A. Bovicelli and R.J. Kurman Chapter 9: 125-153.
  3. C.-F. Hung, R. Calizo, Y.-C. Tsai, L. He, and T.-C. Wu (2007) A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors. Vaccine 25: 127-135.
  4. C.-F. Hung, Y.-C. Tsai, L. He, G. Coukos, I. Fodor, L. Qin, H. Levitsky and T.-C. Wu (2007) Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice. Gene Therapy 14: 20-29.
  5. T. H. Kang, J. H. Lee, C. K. Song, H. D. Han, B. C. Shin, S. I. Pai, C.-F. Hung, C. Trimble, J.-S. Lim, T. W. Kim and T.-C. Wu (2007) Epigallocatechin-3-Gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Research 67: 802-811.
  6. C.-F. Hung, Y.-C. Tsai, L. He, and T.-C. Wu (2007) Control of mesothelin-expressing ovarian cancer using adoptive transfer of mesothelin peptide-specific CD8+ T cells. Gene Therapy 14: 921-929.
  7. K.-Y. Lin, D. Lu, C.-F. Hung, S. Peng, L Huang, C. Jie, F. Murillo, J. Rowley, Y.-C. Tsai, L. He, E. Jaffee, D. M. Pardoll and T.-C. Wu (2007) Ectopic expression of vascular cell adhesion molecule-1 (VCAM-1) as a new mechanism for tumor immune evasion. Cancer Research 67: 1832-1841.
  8. W.-F. Cheng, C.-F. Hung, C.-Y. Chai, C.-A. Chen, C.-N. Lee, Y.-N. Su, W.-Y. I. Tseng, C.-Y. Hsieh, I.-M. Shih, T.-L. Wang and T.-C. Wu (2007) Generation of Mesothelin-Expressing Tumor Model with Intraperitoneal Tumor Growth and Ascites Formation. Cancer 110: 420-431.
  9. S. Peng, C. Trimble, L. Wu, D. Pardoll, C.-F. Hung, and T.-C. Wu (2007) HLA-DQB1*02-Restricted HPV-16 E7 Peptide-specific CD4+ T Cell Immune Responses Correlate with Regression of HPV-16-Associated High Grade Squamous Intraepithelial Lesions. Clinical Cancer Research 13: 2479-2487.
  10. C.-P. Mao, C.-F. Hung and T.-C. Wu (2007) Immunotherapeutic Strategies Employing RNA Interference Technology for the Control of Cancers. J. Biomed. Sci 14: 15-29.
  11. S. W.D. Tsen, C.-F. Hung, and T.-C. Wu (2007) Antigen-specific cancer immunotherapy: HPV-associated cervical cancer as a model system. Book Chapter of Cancer Vaccines and Tumor Immunology, Editors B. Johnson, R. Orentas and J. Hodge Chapter 6.
  12. R. Roden, A. Monie and T.-C. Wu (2007) Human papillomavirus vaccine for cervical cancer prevention. Management of Cervical Cancer. Editor: Dan Longo in Hot Topics in Oncology (in press).
  13. C.-P. Mao, Y.-Y. Lin, C.-F. Hung and T.-C. Wu (2007) Immunological research using RNA interference technology. Immunology. 121: 295-307.
  14. C.-F. Hung, A. Monie and T.-C. Wu (2007) Immunotherapy of Angiogenesis with DNA Vaccines. Book Chapter of Angiogenesis: An integrative approach from science to medicine. Editors: Drs. William D. Figg and Judah Folkman. Springer US (in press).
  15. S.-W. D. Tsen, A. Paik, C.-F. Hung and T-C Wu (2007) Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells. Expert Review of Vaccines 6: 227-239.
  16. R. Roden, A. Monie and T.-C. Wu (2007) Opportunities to improve the prevention and treatment of cervical cancer. Current Molecular Medicine. 7: 490-503.
  17. A. Monie, Chien-Fu Hung and T.-C. Wu (2007) Preventive and Therapeutic HPV Vaccines. Current Opinion in Investigational Drugs 8:1038-50.
  18. C.-F. Hung, A. Monie, R. D. Alvarez and T.-C. Wu (2007) DNA vaccines for cervical cancer: from bench to bedside. Experimental and Molecular Medicine 39: 679-689.
  19. C.-F. Hung, Y.-C. Tsai, L. He, and T.-C. Wu (2007) DNA vaccines encoding Ii-PADRE generates potent PADRE-specific CD4+ T cell immune responses and enhances vaccine potency. Molecular Therapy 15: 1211-1219.
  20. T.-C. Wu (2007) The role of VCAM-1 in tumor Immune evasion. Cancer Research 67: 6003-6007.
  21. D. Kim, C.-F. Hung and T.-C. Wu (2007) Monitoring the trafficking of adoptively transferred antigen-specific CD8-positive T cells in vivo, using noninvasive luminescence imaging. Hum Gene Ther 18: 575-588.
  22. Chang, C.L., T.C. Wu, and C.F. Hung, (2007) Control of human mesothelin-expressing tumors by DNA vaccines. Gene Therapy 14: 1189-1198.
  23. K.T. Tsen, S.-W. D. Tsen, C.-L. Chang, C.-F. Hung, T.-C. Wu and Juliann G. Kiang (2007) Inactivation of viruses by coherent excitations with a low power visible femtosecond laser. Virology J. 4: 50-55.
  24. K.T. Tsen, S.-W. D. Tsen, C.-L. Chang, C.-F. Hung, T.-C. Wu and Juliann G. Kiang (2007) Inactivation of viruses by laser-driven coherent excitations via impulsive stimulated Raman scattering process. Journal of Biomedical Optics 12: 064030.
  25. T. Li, H. Wen, C. Brayton, F. M. Laird, G. Ma, S. Peng, L. Placanica, T.- C. Wu, B. J. Crain, D. L. Price, C. G. Eberhart and P. C. Wong (2007) Moderate reduction of ?-secretase attenuates amyloid burden and limits mechanism-based liabilities. J. Neuroscience. 27: 10849-10859.
  26. C.-L. Chang, Y.-C. Tsai, L. He, T.-C. Wu, and C.-F. Hung (2007) Cancer immunotherapy using irradiated tumor cells secreting Hsp70. Cancer Research 67: 10047-10057.
  27. B. Huang, C.P. Mao, S.W. Peng, L.M. He, C.-F. Hung and T.-C. Wu (2007) Intradermal administration of DNA vaccines combining a strategy to bypass antigen processing with a strategy to prolong dendritic cell survival enhances DNA vaccine potency. Vaccine 25: 7824-7831.
  28. D. Kim, T. Hoory, T.-C. Wu and C.-F. Hung (2007) Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life and intracellular targeting strategies with a strategy to boost CD4+ T cells. Gene Therapy. 18: 1129-1139.
  29. C.-P. Mao, Y.-Y. Lin, C.-F. Hung and T.-C. Wu (2007) Immunological research using RNA interference technology. Immunology. 121: 295-307.
  30. C.-F. Hung, A. Monie and T.-C. Wu (2007) Immunotherapy of Angiogenesis with DNA Vaccines. Book Chapter of Angiogenesis: An integrative approach from science to medicine. Editors: Drs. William D. Figg and Judah Folkman. Springer US. Chapter 39: pp 451-460.
  31. R. Roden, A. Monie and T.-C. Wu (2007) Opportunities to improve the prevention and treatment of cervical cancer. Current Molecular Medicine. 7: 490-503.
  32. A. Monie, Chien-Fu Hung and T.-C. Wu (2007) Preventive and Therapeutic HPV Vaccines. Current Opinion in Investigational Drugs 8:1038-50.
  33. C.-F. Hung, A. Monie, R. D. Alvarez and T.-C. Wu (2007) DNA vaccines for cervical cancer: from bench to bedside. Experimental and Molecular Medicine 39: 679-689.
  34. D. Kim, R. Gambhira, B. Karanam, A. Monie, C.-F. Hung, R. Roden and T.-C. Wu (2008) Generation and characterization of a preventive and therapeutic HPV DNA vaccine. Vaccine 26: 351-360.
  35. D. Kim, A. Monie, L. He, Y.-C. Tsai, C.-F. Hung and T.-C. Wu (2007) Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T cell immune responses. Gene Therapy 15: 677-687.
  36. R. J. Kurman, K. Visvanathan, R. Roden, T.-C. Wu, I.-M. Shih (2007) Early Detection and Treatment of Ovarian Cancer: Shifting from Early Stage to Minimal Volume of Disease Based on a New Model of Carcinogenesis. Am. J. Ob. Gyn. 198(4): 351-356.
  37. S.-W. D. Tsen, C.-F. Hung and T.-C. Wu (2007) Antigen-specific cancer immunotherapy: HPV-associated cervical cancer as a model system. Cancer Vaccines and Tumor Immunity, Edited by Rimas Orentas, James W. Hodge and Bryon D. Johnson. John Wiley& Son, Inc.
  38. A. Monie, C.-F. Hung, R. Roden and T.-C. Wu (2007) Cervarix: A vaccine for the prevention of HPV 16, 18-associated cervical cancer. Biologics: Targets & Therapy.
  39. C.-P. Mao and T.-C. Wu (2007) Molecular pathogenesis of the human papillomavirus. Translational Research in Biomedicine Vol. 1: Human Cancer Viruses Edited by, John Nicholas, Kuan-Teh Jeang and T.-C. Wu., S. Karger AG. 20-36.
  40. R. Roden, C.-F. Hung, A. Monie and T.-C. Wu (2007) HPV Vaccines. Translational Research in Biomedicine Vol. 1: Human Cancer Viruses Edited by, John Nicholas, Kuan-Teh Jeang and T.-C. Wu., S. Karger AG 37-62.
  41. C. Shi, A. Parker, L. Hua, C. Morrell, S.-C. Lee, V. Bandaru, S. J. Dumler, T.-C. Wu, and J. Eshleman (2008) Anti-gene padlocks eliminate Escherichia coli based on their genotype. Journal of Antimicrobial Chemotherapy 61: 262-72.
  42. C.-F. Hung, T.-C. Wu, A. Monie and R. Roden (2008) Antigen-specific immunotherapy of cervical and ovarian cancer. Immunological Reviews 222:43-69.
  43. R. Roden, P. Gravitt and T.-C. Wu (2008) Towards global prevention of HPV-induced cancer. (commentary) European Journal of Immunology 38: 323-326.
  44. S. Peng, C. L. Trimble, R. D. Alvarez, W. K. Huh, Z. Lin, A. Monie, C.-F. Hung and T.-C. Wu (2008) Cluster Intradermal DNA Vaccination Rapidly Induces E7-specific CD8+ T Cell Immune Responses Leading to Therapeutic Antitumor Effects. Gene Therapy 15: 677-687.
  45. T. Hoory, A. Monie, P. Gravitt and T.-C. Wu (2008) Molecular Epidemiology of Human Papillomavirus. Journal of Formosa Medical Association 3: 198-217.
  46. Barbara Ma, Chien-Fu Hung and T.-C. Wu (2008) DNA vaccines for the human papilloma virus. Tumor Associated Antigens-a handbook Edited by Olivier Gires and Seliger. Wiley-VCH (in press).
  47. C.-F. Hung, B. Ma, A. Monie, S.-W. Tsen and T.-C. Wu (2008) Therapeutic HPV vaccines: current clinical trials and future directions. Expert Opinion of Biological Therapy 8: 421-439.
  48. C.-W. Tseng, C.-F. Hung, R. D. Alvarez, C. L. Trimble, W. K. Huh, D. Kim, C.-M. Chuang, C.-T. Lin, Y.-C. Tsai, L. He, A. Monie and T.-C. Wu (2008) Pretreatment with cisplatin enhances E7-specific CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Clinical Cancer Research 14: 3193-3203.
  49. D. Kim, T. Hoory, A. Monie, J. P.-Y. Ting, C.-F. Hung and T.-C. Wu (2008) Enhancement of DNA vaccine potency through co-administration of MHC Class II Transactivator (CIITA) DNA with DNA vaccines via gene gun. Journal of Immunology 180(10): 7019-7027.
  50. D. Kim, A. Monie, Y.-C. Tsai, L. He, M.-C. Wang, C.-F. Hung and T.-C. Wu (2008) Enhancement of CD4+ T cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice. Gene Therapy 15(16): 1176-1183.
  51. B. Huang, C.-P. Mao, S. Peng, M.-C. Wang, C.-F. Hung and T.-C. Wu (2008) RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency. Human Gene Therapy 19(8): 763-773.
  52. C.W. Tseng, A. Monie, C. Trimble, R. D. Alvarez, W. K. Huh, D. J. Buchsbaum, J. M. Straughn Jr., M-C. Wang, H. Yagita, C.-F. Hung and T.-C. Wu (2008) Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects. Vaccine 26(34): 4314-4319.
  53. Y.S. Park, J.h. Lee, C.F. Hung, T.-C. Wu, and T.W. Kim (2008). Enhancement of antibody responses to Bacillus anthracis protective antigen domain IV by use of calreticulin as a chimeric molecular adjuvant. Infect Immun. 76: 1952-1959.
  54. J. Rowley, A. Monie, C.F. Hung and T.-C. Wu (2008) Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans. Journal of Immunology 181(12): 8237-8247.
  55. C.W. Tseng, A. Monie, C.Y. Wu, B. Huang, M-C. Wang, C.F. Hung and T.-C. Wu (2008) Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Journal of Molecular Medicine 86(8): 899-908.
  56. C.W Tseng, C. Trimble, Q. Zeng, A. Monie, R.D. Alvarez, W.K. Huh, T. Hoory, M.C. Wang, C.-F. Hung and T.-C. Wu (2008) Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother (Epub ahead of print)
  57. C. L. Trimble, S. Peng, F. Kos, P. Gravitt, R. Viscidi, E. Sugar, D. Pardoll, T.-C. Wu (2008) A phase I trial of a HPV DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clinical Cancer Research 15(1): 361-367.
  58. Kyung Hee Noh, Tae Heung Kang, Jin Hee Kim, Sara I. Pai, Ken Y. Lin, Chien-Fu Hung, T.-C. Wu and Tae Woo Kim. Activation of Akt as a mechanism for tumor immune evasion. Molecular Therapy (Epub ahead of print).
  59. J. Rowley, A. Monie, C.F. Hung and T.-C. Wu (2008) Expression of IL-15Rα or an IL-15/IL-15Rα fusion can promote IL-15 mediated survival and proliferation of CD8+ T cell in cis. European Journal of Immunology (in press)
Last Modified: January 30, 2009   © COPYRIGHT 2006-2009 JHMI