Epitheliod Trophoblastic Tumor (ETT)
Clinical features:
-
Reproductive ages,
antecedent pregnancy can be remote
- Abnormal vaginal bleeding
- Low serum b-hCG (50 - 500 IU/ML)
- Frequently occurs in cervix or LUS
- 15-20% ETTs are malignant
- Hysterectomy or local excision
Gross features:
50% in lower uterine segment or endocervix
Solitary nodule
Hemorrhage and necrosis
33 y/o female with abnormal bleeding
Endometrial D&C- ETT (3 yrs ago)
Abnormal chest x-ray
Serum beta-hCG- 0
Lung resection
Nodular and well circumscribed, expansile margin
Extensive geographic necrosis with focal dystrophic calcification
Nests or cords of atypical mononucleated trophoblastic cells
surrounding dense fibrillar eosinophilic debris (material)
Round, uniform nuclei, eosinophilic or clear cytoplasm,
well-defined cell membrane
Occasional mitoses (0-9 / 10 HPF)
Tumor cells surround the vessel, but not invade
Extensive geographic necrosis with focal dystrophic calcification
Nests of atypical mononucleated trophoblastic cells
surrounding dense fibrillar eosinophilic debris (material)
Nests of atypical mononucleated trophoblastic cells
surrounding dense fibrillar eosinophilic debris (material)
atypical mononucleated trophoblastic cells
surrounding dense fibrillar eosinophilic material
eosinophilic or clear cytoplasm, well-defined cell membrane
Occasional mitoses (0-9 / 10 HPF)
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