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Edited by Ie-Ming Shih, MD, PhD
Division of Gynecologic Pathology
Department of Pathology
Johns Hopkins Medical Institutions
E-mail: ishih@jhmi.edu
Tel: (410) 502-7774
1503 E. Jefferson Street, B-315
Baltimore, MD 21231
Lab website: http://pathology2.jhu.edu/shihlab
Special thanks to Dr. Chih-Yi Hsu for his efforts in photomicrographs and legends
Webmaster; Jennifer Parsons Brumbaugh
Diagnostic pathologists in Gynecological Pathology Division
at the Johns Hopkins Hospital:
Robert J. Kurman, MD, Director
Brigitte Ronnett, MD
Ie-Ming Shih, MD, PhD
Russell Vang, MD
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Exaggerated Placental Site
- Defined by an exuberant number of implantation site IT
- Numerous multinucleated IT
- A physiological process without clinical significance
- Differential diagnosis with PSTT
- presence of villi or fetal parts
- absence of proliferation
- less cytological atypia
- abundant multinucleated IT
- b-hCG continues to decline
mono- or multinucleated trophoblastic cells infiltrate the muscle
no confluent growth, no necrosis
trophoblastic cells infiltrate decidua
no confluent growth, no necrosis
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