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Edited by Ie-Ming Shih, MD, PhD
Division of Gynecologic Pathology
Department of Pathology
Johns Hopkins Medical Institutions
E-mail: ishih@jhmi.edu
Tel: (410) 502-7774
1503 E. Jefferson Street, B-315
Baltimore, MD 21231
Lab website: http://pathology2.jhu.edu/shihlab
Special thanks to Dr. Chih-Yi Hsu for his efforts in photomicrographs and legends
Webmaster; Jennifer Parsons Brumbaugh
Diagnostic pathologists in Gynecological Pathology Division
at the Johns Hopkins Hospital:
Robert J. Kurman, MD, Director
Brigitte Ronnett, MD
Ie-Ming Shih, MD, PhD
Russell Vang, MD
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Placental Site Nodule
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Lesions of chorionic-type IT, usually small
- 40-50% of PSNs are found in cervix
- Always incidental findings
- Complete excision after surgical procedures
- No clinical follow-up required
- Differential diagnosis:
- cervical carcinoma,
- epithelioid trophoblastic tumor
- other uterine tumors
Placental Site Nodule/Plaque
A. Well-circumscribed lesion with acellular material in the center
B. Hyaline material containing scattered chorionic-type IT
C. Chorionic-type IT with smudged nuclei,indistinct cell border,
mitosis is absent
Placental site nodule in endometrial curretage
Well-circumscribed, acellular center containing
scattered chorionic-type IT
Placental site nodule in endometrial curretage
Placental site nodule in ectopic tubal pregnancy
Well-circumscribed, acellular center containing
scattered chorionic-type IT
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