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Pathology of Gestational Trophoblastic Lesions

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Edited by Ie-Ming Shih, MD, PhD
Division of Gynecologic Pathology
Department of Pathology
Johns Hopkins Medical Institutions
E-mail: ishih@jhmi.edu
Tel: (410) 502-7774
1503 E. Jefferson Street, B-315
Baltimore, MD 21231

Lab website: http://pathology2.jhu.edu/shihlab

Special thanks to Dr. Chih-Yi Hsu for his efforts in photomicrographs and legends
Webmaster; Jennifer Parsons Brumbaugh

Diagnostic pathologists in Gynecological Pathology Division
at the Johns Hopkins Hospital:
Robert J. Kurman, MD, Director
Brigitte Ronnett, MD
Ie-Ming Shih, MD, PhD
Russell Vang, MD



Placental Site Nodule

  • Lesions of chorionic-type IT, usually small
  • 40-50% of PSNs are found in cervix
  • Always incidental findings
  • Complete excision after surgical procedures
  • No clinical follow-up required
  • Differential diagnosis:
    • cervical carcinoma,
    • epithelioid trophoblastic tumor
    • other uterine tumors
Placental Site Nodule/Plaque

A. Well-circumscribed lesion with acellular material in the center
B. Hyaline material containing scattered chorionic-type IT
C. Chorionic-type IT with smudged nuclei,indistinct cell border, mitosis is absent


Placental site nodule in endometrial curretage Well-circumscribed, acellular center containing scattered chorionic-type IT


Placental site nodule in endometrial curretage


Placental site nodule in ectopic tubal pregnancy Well-circumscribed, acellular center containing scattered chorionic-type IT